scholarly journals Spectroscopic and Theoretical Study of CuIBinding to His111 in the Human Prion Protein Fragment 106–115

2016 ◽  
Vol 55 (6) ◽  
pp. 2909-2922 ◽  
Author(s):  
Trinidad Arcos-López ◽  
Munzarin Qayyum ◽  
Lina Rivillas-Acevedo ◽  
Marco C. Miotto ◽  
Rafael Grande-Aztatzi ◽  
...  
Keyword(s):  
Prion Protein ◽  
Theoretical Study ◽  
Protein Fragment ◽  
Human Prion Protein

scholarly journals Sulphated glycosaminoglycans prevent the neurotoxicity of a human prion protein fragment

1998 ◽  
Vol 335 (2) ◽  
pp. 369-374 ◽  
Author(s):  
Mar PÉREZ ◽  
Francisco WANDOSELL ◽  
Camilo COLAÇO ◽  
Jesús AVILA
Keyword(s):  
Prion Protein ◽  
Amyloid Fibrils ◽  
Transmissible Spongiform Encephalopathies ◽  
Therapeutic Effects ◽  
Protein Fragment ◽  
Spongiform Encephalopathies ◽  
Sulphated Polysaccharides ◽  
Human Prion Protein ◽  
Sulphated Glycosaminoglycans

Although a number of features distinguish the disease isoform of the prion protein (PrPSc) from its normal cellular counterpart (PrPC) in the transmissible spongiform encephalopathies (TSEs), the neuropathogenesis of these diseases remains an enigma. The amyloid fibrils formed by fragments of human PrP have, however, been shown to be directly neurotoxic in vitro. We show here that sulphated polysaccharides (heparin, keratan and chondroitin) inhibit the neurotoxicity of these amyloid fibrils and this appears to be mediated via inhibition of the polymerization of the PrP peptide into fibrils. This provides a rationale for the therapeutic effects of sulphated polysaccharides and suggests a rapid in vitro functional screen for TSE therapeutics.

scholarly journals Metal-Binding Ability of Human Prion Protein Fragment Peptides Analyzed by Column Switch HPLC

2011 ◽  
Vol 59 (8) ◽  
pp. 965-971 ◽  
Author(s):  
Aya Kojima ◽  
Yasunori Mabuchi ◽  
Motomi Konishi ◽  
Rika Okihara ◽  
Makoto Nagano ◽  
...  
Keyword(s):  
Prion Protein ◽  
Metal Binding ◽  
Protein Fragment ◽  
Binding Ability ◽  
Human Prion Protein ◽  
Metal Binding Ability

Spectroscopic and Electronic Structure Studies of Copper(II) Binding to His111 in the Human Prion Protein Fragment 106−115: Evaluating the Role of Protons and Methionine Residues

2011 ◽  
Vol 50 (5) ◽  
pp. 1956-1972 ◽  
Author(s):  
Lina Rivillas-Acevedo ◽  
Rafael Grande-Aztatzi ◽  
Italia Lomelí ◽  
Javier E. García ◽  
Erika Barrios ◽  
...  
Keyword(s):  
Electronic Structure ◽  
Prion Protein ◽  
Protein Fragment ◽  
Human Prion Protein ◽  
Methionine Residues

Recombinant Human Prion Protein Fragment 90–231, a Useful Model to Study Prion Neurotoxicity

2012 ◽  
Vol 16 (1-2) ◽  
pp. 50-59 ◽  
Author(s):  
Alessandro Corsaro ◽  
Stefano Thellung ◽  
Valentina Villa ◽  
Mario Nizzari ◽  
Antonio Aceto ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Fragment ◽  
Human Prion Protein

scholarly journals PACAP protects neuronal PC12 cells from the cytotoxicity of human prion protein fragment 106-126

FEBS Letters ◽  
2002 ◽  
Vol 522 (1-3) ◽  
pp. 65-70 ◽  
Author(s):  
Satomi Onoue ◽  
Keiichi Ohshima ◽  
Kosuke Endo ◽  
Takehiko Yajima ◽  
Kazuhisa Kashimoto
Keyword(s):  
Pc12 Cells ◽  
Prion Protein ◽  
Protein Fragment ◽  
Human Prion Protein ◽  
Neuronal Pc12 Cells

scholarly journals Hypoxia protects neuronal cells from human prion protein fragment-induced apoptosis

2010 ◽  
Vol 112 (3) ◽  
pp. 715-722 ◽  
Author(s):  
Jae-Suk Seo ◽  
Jae-Won Seol ◽  
Myung-Hee Moon ◽  
Jae-Kyo Jeong ◽  
You-Jin Lee ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Protein Fragment ◽  
Human Prion Protein ◽  
Induced Apoptosis

Conformation Dependent Pro-Apoptotic Activity of the Recombinant Human Prion Protein Fragment 90-231

2006 ◽  
Vol 19 (2) ◽  
pp. 339-356 ◽  
Author(s):  
A. Corsaro ◽  
D. Paludi ◽  
V. Villa ◽  
C. D'Arrigo ◽  
K. Chiovitti ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Fragment ◽  
Human Prion Protein ◽  
Apoptotic Activity
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