Kinetico-mechanistic Study on the Oxidation of Biologically Active Iron(II) Bis(thiosemicarbazone) Complexes by Air. Importance of NH···O2 Interactions As Established by Activation Volumes

2017 ◽  
Vol 56 (22) ◽  
pp. 14284-14290 ◽  
Author(s):  
Paul V. Bernhardt ◽  
Miguel A. Gonzálvez ◽  
Manuel Martínez
Keyword(s):  
Biologically Active ◽  
Mechanistic Study ◽  
Active Iron ◽  
Thiosemicarbazone Complexes

Proton-assisted air oxidation mechanisms of iron(ii) bis-thiosemicarbazone complexes at physiological pH: a kinetico-mechanistic study

2019 ◽  
Vol 48 (44) ◽  
pp. 16578-16587 ◽  
Author(s):  
Miguel A. Gonzálvez ◽  
Andrés G. Algarra ◽  
Manuel G. Basallote ◽  
Paul V. Bernhardt ◽  
María J. Fernández-Trujillo ◽  
...  
Keyword(s):  
Biologically Active ◽  
Mechanistic Study ◽  
Air Oxidation ◽  
Kinetics Of Oxidation ◽  
Thiosemicarbazone Complexes ◽  
Kinetics Of ◽  
Oxidation Mechanisms

The kinetics of oxidation of different biologically-active FeII bis-thiosemicarbazone complexes in water has been monitored at varying dioxygen concentration, temperature, pressure, and pH.

scholarly journals Synthesis of 1-(1-Arylvinyl)pyridin-2(1H)-ones from Ketones and 2-Fluoropyridine

2021 ◽  
Author(s):  
Takuji Kawamoto ◽  
shunya ikeda ◽  
Akio Kamimura
Keyword(s):  
Biologically Active ◽  
Mechanistic Study ◽  
Efficient Procedure ◽  
Benzene Rings ◽  
Synthetic Intermediates ◽  
Alkylation Reactions ◽  
Vinyl Triflates

Pyridone skeletons are found in numerous biologically active molecules and pharmaceuticals. 1-(1-Arylvinyl)pyridin-2(<i>1H</i>)-ones are synthetic intermediates derived from the enamide moiety, and only few examples of the synthesis of 1-(1-arylvinyl)-2-pyridones have been reported. In this work, a simple and efficient procedure for the synthesis of <i>N</i>-vinyl-substituted pyridones from ketones and 2-fluoropyridine in the presence of trifluoromethane sulfonic anhydride, followed by base treatment is described. Various ketones with electron-donating or -withdrawing groups at the benzene rings can be used in this reaction. A preliminary mechanistic study indicates that it is not very likely that both vinyl triflates and vinyl cations play major roles as intermediates in this transformation. The thus obtained pyridones can be subsequently transformed via C–H arylation and radical alkylation reactions.

scholarly journals Synthesis of 1-(1-Arylvinyl)pyridin-2(1H)-ones from Ketones and 2-Fluoropyridine

2021 ◽  
Author(s):  
Takuji Kawamoto ◽  
shunya ikeda ◽  
Akio Kamimura
Keyword(s):  
Biologically Active ◽  
Mechanistic Study ◽  
Efficient Procedure ◽  
Benzene Rings ◽  
Synthetic Intermediates ◽  
Alkylation Reactions ◽  
Vinyl Triflates

Pyridone skeletons are found in numerous biologically active molecules and pharmaceuticals. 1-(1-Arylvinyl)pyridin-2(<i>1H</i>)-ones are synthetic intermediates derived from the enamide moiety, and only few examples of the synthesis of 1-(1-arylvinyl)-2-pyridones have been reported. In this work, a simple and efficient procedure for the synthesis of <i>N</i>-vinyl-substituted pyridones from ketones and 2-fluoropyridine in the presence of trifluoromethane sulfonic anhydride, followed by base treatment is described. Various ketones with electron-donating or -withdrawing groups at the benzene rings can be used in this reaction. A preliminary mechanistic study indicates that it is not very likely that both vinyl triflates and vinyl cations play major roles as intermediates in this transformation. The thus obtained pyridones can be subsequently transformed via C–H arylation and radical alkylation reactions.

Transition-metal-free persulfuration to construct unsymmetrical disulfides and mechanistic study of the sulfur redox process

2015 ◽  
Vol 51 (20) ◽  
pp. 4208-4211 ◽  
Author(s):  
Xiao Xiao ◽  
Minghao Feng ◽  
Xuefeng Jiang
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Redox Process ◽  
Biologically Active ◽  
New Method ◽  
Mechanistic Study ◽  
Metal Free ◽  
Active Moiety

A sulfur redox process has been developed between sulfinate and thiosulfate, which efficiently affords diverse unsymmetrical disulfides and provides a new method to modify pharmaceuticals and natural products with this biologically active moiety without extra oxidant or reductant.

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