Reducing the emissions of greenhouse gas is a worldwide problem that needs to be solved urgently for sustainable development in the future. The solubility of CO2 in ionic liquids is one of the important basic data for capturing CO2. Considering the disadvantages of experimental measurements, e.g., time-consuming and expensive, the complex parameters of mechanism modeling and the poor stability of single data-driven modeling, a multi-model fusion modeling method is proposed in order to predict the solubility of CO2 in ionic liquids. The multiple sub-models are built by the training set. The sub-models with better performance are selected through the validation set. Then, linear fusion models are established by minimizing the sum of squares of the error and information entropy method respectively. Finally, the performance of the fusion model is verified by the test set. The results showed that the prediction effect of the linear fusion models is better than that of the other three optimal sub-models. The prediction effect of the linear fusion model based on information entropy method is better than that of the least square error method. Through the research work, an effective and feasible modeling method is provided for accurately predicting the solubility of CO2 in ionic liquids. It can provide important basic conditions for evaluating and screening higher selective ionic liquids.