Synthesis and Structure–Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects

Structure Activity ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor ◽

In vivo effects of μ-opioid receptor agonist/δ-opioid receptor antagonist peptidomimetics following acute and repeated administration

British Journal of Pharmacology ◽

10.1111/bph.14148 ◽

2018 ◽

Vol 175 (11) ◽

pp. 2013-2027 ◽

Cited By ~ 20

Author(s):

Jessica P Anand ◽

Kelsey E Kochan ◽

Anthony F Nastase ◽

Deanna Montgomery ◽

Nicholas W Griggs ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Repeated Administration ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor ◽

Δ Opioid Receptor ◽

In Vivo Effects

Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist

Psychopharmacology ◽

10.1007/s00213-020-05638-1 ◽

2020 ◽

Vol 237 (12) ◽

pp. 3591-3602

Author(s):

Sanjana Mada ◽

Lisa R. Gerak ◽

Amélie Soyer ◽

David R. Maguire ◽

Zehua Hu ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Behavioral Effects ◽

Opioid Receptor Agonist ◽

Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine

European Journal of Pharmacology ◽

10.1016/j.ejphar.2020.172918 ◽

2020 ◽

Vol 871 ◽

pp. 172918 ◽

Cited By ~ 1

Author(s):

Mohammad Zafar Imam ◽

Andy Kuo ◽

Sussan Ghassabian ◽

Yunxin Cai ◽

Yajuan Qin ◽

...

Keyword(s):

Receptor Antagonist ◽

Respiratory Depression ◽

Opioid Receptor ◽

Opioid Receptors ◽

Receptor Agonist ◽

Intracerebroventricular Administration ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor

Effectiveness of nalbuphine, a κ‐opioid receptor agonist and μ‐opioid receptor antagonist, in the inhibition of I Na , I K(M) , and I K(erg) unlinked to interaction with opioid receptors

Drug Development Research ◽

10.1002/ddr.21568 ◽

2019 ◽

Vol 80 (6) ◽

pp. 846-856 ◽

Cited By ~ 1

Author(s):

Yuan‐Yuarn Liu ◽

Hung‐Tsung Hsiao ◽

Jeffery C.‐F. Wang ◽

Yen‐Chin Liu ◽

Sheng‐Nan Wu

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Opioid Receptors ◽

Receptor Agonist ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor

Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.116.236547 ◽

2016 ◽

Vol 359 (3) ◽

pp. 471-481 ◽

Cited By ~ 15

Author(s):

N. Levy-Cooperman ◽

G. McIntyre ◽

L. Bonifacio ◽

M. McDonnell ◽

J. M. Davenport ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Abuse Potential ◽

Opioid Receptor Agonist ◽

New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline

Expert Review of Gastroenterology & Hepatology ◽

10.1080/17474124.2017.1298442 ◽

2017 ◽

Vol 11 (4) ◽

pp. 285-292 ◽

Cited By ~ 4

Author(s):

Maura Corsetti ◽

Peter Whorwell

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Therapeutic Options ◽

Opioid Receptor Agonist ◽

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.12.049 ◽

2015 ◽

Vol 92 ◽

pp. 270-281 ◽

Cited By ~ 10

Author(s):

Miao Hu ◽

Marc A. Giulianotti ◽

Jay P. McLaughlin ◽

Jiaan Shao ◽

Ginamarie Debevec ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Opioid Receptor Agonist ◽

Rational Drug Design of δ Opioid Receptor Agonist TAN-67 from δ Opioid Receptor Antagonist NTI

Topics in Heterocyclic Chemistry - Bioactive Heterocycles II ◽

10.1007/7081_2007_049 ◽

2007 ◽

pp. 99-125 ◽

Cited By ~ 1

Author(s):

Hiroshi Nagase ◽

Hideaki Fujii

Keyword(s):

Drug Design ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Rational Drug Design ◽

Opioid Receptor Agonist ◽

Rational Drug ◽

Itching-like behavior: A common effect of the kappa opioid receptor antagonist 5'-guanidinonaltrindole and the biased kappa opioid receptor agonist 6'-guanidinonaltrindole in mice

Medicine in Drug Discovery ◽

10.1016/j.medidd.2021.100097 ◽

2021 ◽

pp. 100097

Author(s):

Alan Cowan ◽

Lee-Yuan Liu-Chen ◽

Saadet Inan

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Common Effect ◽

Opioid Receptor Agonist

5-Benzyl substituted 14-methoxymetopon, a high affinity μ opioid receptor agonist with potent antinociceptive activity in mice

BMC Pharmacology ◽

10.1186/1471-2210-8-s1-a29 ◽

2008 ◽

Vol 8 (Suppl 1) ◽

pp. A29

Author(s):

Mariana Spetea ◽

Catalina-Roxana Bohotin ◽

Helmut Schmidhammer

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Antinociceptive Activity ◽

High Affinity ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor