2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b00573 ◽

2015 ◽

Vol 58 (14) ◽

pp. 5548-5560 ◽

Author(s):

Soosung Kang ◽

Huiying Li ◽

Wei Tang ◽

Pavel Martásek ◽

Linda J. Roman ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Inhibitory Potency ◽

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Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(01)00680-1 ◽

2002 ◽

Vol 12 (1) ◽

pp. 13-16 ◽

Author(s):

Anna Palumbo ◽

Alessandra Napolitano ◽

Marco d'Ischia

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Competitive Inhibitors ◽

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Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure

Brain Research ◽

10.1016/s0006-8993(96)00620-8 ◽

1996 ◽

Vol 734 (1-2) ◽

pp. 109-115 ◽

Author(s):

K Patel

Keyword(s):

Gene Expression ◽

Nitric Oxide ◽

Heart Failure ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

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Role of neuronal nitric oxide synthase in gastric hypermotility induced by intracisternal TRH analog, RX 77368, in anesthetized rats

Gastroenterology ◽

10.1016/s0016-5085(01)82651-2 ◽

2001 ◽

Vol 120 (5) ◽

pp. A533-A534

Author(s):

K KANAMOTO ◽

K KAWAKUBO ◽

D ADELSON ◽

Y TACHE

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Anesthetized Rats ◽

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Optical density analysis of levels of neuronal nitric oxide synthase (nNOS), substance P (SP) and catechoalmines in myenteric ganglia of lleum, proximal colon (PC) and distal colon (DC) from vehicle-and streptozotocin (STZ)-treated guinea pigs

Gastroenterology ◽

10.1016/s0016-5085(01)81666-8 ◽

2001 ◽

Vol 120 (5) ◽

pp. A335-A335

Author(s):

K LEPARD ◽

R PORTER

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Substance P ◽

Guinea Pigs ◽

Neuronal Nitric Oxide Synthase ◽

Distal Colon ◽

Proximal Colon ◽

Density Analysis ◽

Oxide Synthase ◽

Myenteric Ganglia

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Colocalization of neuronal nitric oxide synthase and calretinin in the mouse hippocampus: quantitative and morphometric analysis with optical disector

Neuroscience Research ◽

10.1016/s0168-0102(00)81186-4 ◽

2000 ◽

Vol 38 ◽

pp. S57

Author(s):

S Jinno

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Morphometric Analysis ◽

Neuronal Nitric Oxide Synthase ◽

Optical Disector ◽

Mouse Hippocampus ◽

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Effects of endothelial and neuronal nitric oxide synthase inhibitors on release of amino acids from hippocampus after transient forebrain ischemia

Neuroscience Research ◽

10.1016/s0168-0102(00)81713-7 ◽

2000 ◽

Vol 38 ◽

pp. S144

Author(s):

M Jiang

Keyword(s):

Nitric Oxide ◽

Amino Acids ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Forebrain Ischemia ◽

Nitric Oxide Synthase Inhibitors ◽

Transient Forebrain Ischemia ◽

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Faculty Opinions recommendation of Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031032.363473 ◽

2006 ◽

Author(s):

Henry Lin

Keyword(s):

Nitric Oxide ◽

Stem Cell ◽

Nitric Oxide Synthase ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Neural Stem Cell ◽

Neuronal Nitric Oxide Synthase ◽

Gastric Function ◽

Oxide Synthase ◽

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Faculty Opinions recommendation of Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1082853.542682 ◽

2007 ◽

Author(s):

Arthur Christopoulos

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Serotonin Transporter ◽

Neuronal Nitric Oxide Synthase ◽

Physical Interaction ◽

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Faculty Opinions recommendation of Nuclear recruitment of neuronal nitric-oxide synthase by α-syntrophin is crucial for the induction of mitochondrial biogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718176862.793531928 ◽

2017 ◽

Author(s):

Yin Hua Zhang

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Mitochondrial Biogenesis ◽

Neuronal Nitric Oxide Synthase ◽

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Effect of Scrapie Infection on the Activity of Neuronal Nitric-oxide Synthase in Brain and Neuroblastoma Cells

Journal of Biological Chemistry ◽

10.1074/jbc.271.28.16856 ◽

1996 ◽

Vol 271 (28) ◽

pp. 16856-16861 ◽

Author(s):

Haim Ovadia ◽

Hana Rosenmann ◽

Elias Shezen ◽

Michele Halimi ◽

Ishai Ofran ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Neuroblastoma Cells ◽

Neuronal Nitric Oxide Synthase ◽

Scrapie Infection ◽

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