scholarly journals Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase

2016 ◽  
Vol 59 (6) ◽  
pp. 2579-2595 ◽  
Author(s):  
Philippe Diaz ◽  
Weize Huang ◽  
Charles M. Keyari ◽  
Brian Buttrick ◽  
Lauren Price ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Retinoic Acid ◽  
Human Liver ◽  
Selective Inhibitors

scholarly journals Characterization of O-demethylations and Aromatic Hydroxylations Mediated by Cytochromes P450 in the Metabolism of Flavonoid Aglycons

2019 ◽  
Vol 92 (1) ◽  
pp. 115-123 ◽  
Author(s):  
Goran Benković ◽  
Hrvoje Rimac ◽  
Željan Maleš ◽  
Siniša Tomić ◽  
Zoran Lončar ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Cytochromes P450 ◽  
Liver Microsomes ◽  
Cytochrome P450 Enzymes ◽  
Uv Detector ◽  
Aromatic Hydroxylation ◽  
Metabolism Of Xenobiotics ◽  
Kinetics Of

One of the most important groups of metabolic enzymes is cytochrome P450 superfamily. These enzymes are important in terms of the catalytic diversity and the large number of xenobiotics that are detoxified or activated by converting to reactive metabolites. Flavonoids are xenobiotics to which humans are exposed through diet. Data on their oxidative metabolism mediated by cytochromes P450 are limited. The aim of this study was to determine the enzymatic kinetics of O-demethylation and aromatic hydroxylation of flavonoid aglycons on recombinant cytochrome P450 enzymes and human liver microsomes systems. The study was performed on ten flavonoids, namely 3,7-dihydroxyflavone, 7-hydroxyflavone, acacetin, apigenin, flavone, galangin, kaempferol, naringenin, sakuranetin, and tangeretin using liquid chromatography coupled with mass spectrometry and UV detector. Most relevant enzyme involved in metabolism of flavonoid aglycons is CYP1A2, and its catalytic effectiveness ranges from 0.5 to 2.9 × 106 M–1 min–1. Having in mind high expression and involvement of CYP1A2 in metabolism of xenobiotics including drugs, and its intraindividual differences in expression and activity, potential of drug-flavonoid competitive interactions/inhibitions should be considered when consuming dietary supplement and foods rich in flavonoids.

Biochemical Characterization of the Human Liver Cytochrome P450 Arachidonic Acid Epoxygenase Pathway

1996 ◽  
Vol 330 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Darryl C. Zeldin ◽  
Cindy R. Moomaw ◽  
Nate Jesse ◽  
Kenneth B. Tomer ◽  
Jeffrey Beetham ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Cytochrome P450 ◽  
Human Liver ◽  
Biochemical Characterization ◽  
Liver Cytochrome

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

1991 ◽  
Vol 200 (2) ◽  
pp. 511-517 ◽  
Author(s):  
Manuelle MAURICE ◽  
Stephane EMILIANI ◽  
Isabelle DALET-BELUCHE ◽  
Jean DERANCOURT ◽  
Reinhard LANGE
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Isolation And Characterization

Characterization of the Cytochrome P450 CYP2J4: Expression in Rat Small Intestine and Role in Retinoic Acid Biotransformation from Retinal

1998 ◽  
Vol 353 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Qing-Yu Zhang ◽  
Gregory Raner ◽  
Xinxin Ding ◽  
Deborah Dunbar ◽  
Minor J. Coon ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Small Intestine ◽  
Retinoic Acid ◽  
Rat Small Intestine

In vitrometabolism of magnolin and characterization of cytochrome P450 enzymes responsible for its metabolism in human liver microsomes

Xenobiotica ◽  
2011 ◽  
Vol 41 (5) ◽  
pp. 358-371 ◽  
Author(s):  
Dong Kyun Kim ◽  
Kwang-Hyeon Liu ◽  
Ji Hyun Jeong ◽  
Hye Young Ji ◽  
Sei-Ryang Oh ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzymes

scholarly journals Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

2009 ◽  
Vol 77 (2) ◽  
pp. 258-268 ◽  
Author(s):  
Justin D. Lutz ◽  
Vaishali Dixit ◽  
Catherine K. Yeung ◽  
Leslie J. Dickmann ◽  
Alex Zelter ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Retinoic Acid ◽  
Functional Characterization
Sign in / Sign up

Export Citation Format

Share Document