Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action

Akira Kato; Makiko Yamao; Yuta Hashihara; Hiroaki Ishida; Toshimasa Itoh; Keiko Yamamoto

doi:10.1021/acs.jmedchem.7b00819

Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00819 ◽

2017 ◽

Vol 60 (20) ◽

pp. 8394-8406 ◽

Cited By ~ 4

Author(s):

Akira Kato ◽

Makiko Yamao ◽

Yuta Hashihara ◽

Hiroaki Ishida ◽

Toshimasa Itoh ◽

...

Keyword(s):

Crystal Structure ◽

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Antagonistic Action ◽

Receptor Ligand ◽

Vitamin D Analogues

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Crystal Structure of the Vitamin D Receptor Ligand-Binding Domain with Lithocholic Acids

Vitamin D Hormone - Vitamins & Hormones ◽

10.1016/bs.vh.2015.10.004 ◽

2016 ◽

pp. 117-136 ◽

Cited By ~ 4

Author(s):

Teikichi Ikura ◽

Nobutoshi Ito

Keyword(s):

Crystal Structure ◽

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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Mechanism of Vitamin D Receptor Ligand-Binding Domain Regulation Studied by gREST Simulations

Journal of Chemical Information and Modeling ◽

10.1021/acs.jcim.1c00534 ◽

2021 ◽

Author(s):

Toru Ekimoto ◽

Takafumi Kudo ◽

Tsutomu Yamane ◽

Mitsunori Ikeguchi

Keyword(s):

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.020522697 ◽

2000 ◽

Vol 97 (4) ◽

pp. 1467-1472 ◽

Cited By ~ 50

Author(s):

K. Yamamoto ◽

H. Masuno ◽

M. Choi ◽

K. Nakashima ◽

T. Taga ◽

...

Keyword(s):

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Three Dimensional ◽

Binding Domain ◽

Ligand Binding Domain ◽

Ligand Docking ◽

Receptor Ligand ◽

Three Dimensional Modeling ◽

Dimensional Modeling

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A Unique Insertion/Substitution in Helix H1 of the Vitamin D Receptor Ligand Binding Domain in a Patient With Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets

Journal of Bone and Mineral Research ◽

10.1359/jbmr.2004.19.6.1018 ◽

2004 ◽

Vol 19 (6) ◽

pp. 1018-1024 ◽

Cited By ~ 36

Author(s):

Peter J Malloy ◽

Rong Xu ◽

Andreina Cattani ◽

M Loreto Reyes ◽

David Feldman

Keyword(s):

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Resistant Rickets

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Analysis of Molecular Mechanism of Cancer Cell Differentiation and Apoptosis Induced by Vitamin D3 Analogs on the Basis of Molecular Recognition of Vitamin D Receptor Ligand Binding Domain

YAKUGAKU ZASSHI ◽

10.1248/yakushi.122.781 ◽

2002 ◽

Vol 122 (10) ◽

pp. 781-791 ◽

Cited By ~ 4

Author(s):

Kimie NAKAGAWA

Keyword(s):

Vitamin D ◽

Cell Differentiation ◽

Molecular Recognition ◽

Ligand Binding ◽

Molecular Mechanism ◽

Cancer Cell ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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Molecular Structure of the Rat Vitamin D Receptor Ligand Binding Domain Complexed with 2-Carbon-Substituted Vitamin D3Hormone Analogues and a LXXLL-Containing Coactivator Peptide†,‡

Biochemistry ◽

10.1021/bi036056y ◽

2004 ◽

Vol 43 (14) ◽

pp. 4101-4110 ◽

Cited By ~ 136

Author(s):

Janeen L. Vanhooke ◽

Matthew M. Benning ◽

Cary B. Bauer ◽

J. Wesley Pike ◽

Hector F. DeLuca

Keyword(s):

Molecular Structure ◽

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by a Combination Andlysis of MD Simulations and SAXS Experiments

Biophysical Journal ◽

10.1016/j.bpj.2016.11.298 ◽

2017 ◽

Vol 112 (3) ◽

pp. 48a

Author(s):

Yasuaki Anami ◽

Nobutaka Shimizu ◽

Toru Ekimoto ◽

Daichi Egawa ◽

Toshimasa Itoh ◽

...

Keyword(s):

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Md Simulations ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Antagonist Binding

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Relationship between Structure and Conformational Change of the Vitamin D Receptor Ligand Binding Domain in 1α,25-Dihydroxyvitamin D3 Signaling

Molecules ◽

10.3390/molecules201119713 ◽

2015 ◽

Vol 20 (11) ◽

pp. 20473-20486 ◽

Cited By ~ 5

Author(s):

Lin-Yan Wan ◽

Yan-Qiong Zhang ◽

Meng-Di Chen ◽

You-Qin Du ◽

Chang-Bai Liu ◽

...

Keyword(s):

Vitamin D ◽

Ligand Binding ◽

Conformational Change ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Dihydroxyvitamin D3

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Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives

The Journal of Lipid Research ◽

10.1194/jlr.m038307 ◽

2013 ◽

Vol 54 (8) ◽

pp. 2206-2213 ◽

Cited By ~ 28

Author(s):

Hiroyuki Masuno ◽

Teikichi Ikura ◽

Daisuke Morizono ◽

Isamu Orita ◽

Sachiko Yamada ◽

...

Keyword(s):

Vitamin D ◽

Ligand Binding ◽

Crystal Structures ◽

Vitamin D Receptor ◽

Lithocholic Acid ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor

Organic & Biomolecular Chemistry ◽

10.1039/c8ob00158h ◽

2018 ◽

Vol 16 (14) ◽

pp. 2448-2455 ◽

Cited By ~ 2

Author(s):

Daisuke Sawada ◽

Shinji Kakuda ◽

Akiko Takeuchi ◽

Fumihiro Kawagoe ◽

Midori Takimoto-Kamimura ◽

...

Keyword(s):

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Functional Group ◽

Crystallographic Analysis ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

X Ray

Interaction of the 2-functional group of tachysterol analogs in the vitamin D receptor ligand binding domain: X-ray co-crystallographic analysis.

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