Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor

2018 ◽  
Vol 16 (14) ◽  
pp. 2448-2455 ◽  
Author(s):  
Daisuke Sawada ◽  
Shinji Kakuda ◽  
Akiko Takeuchi ◽  
Fumihiro Kawagoe ◽  
Midori Takimoto-Kamimura ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ligand Binding ◽  
Vitamin D Receptor ◽  
Functional Group ◽  
Crystallographic Analysis ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
X Ray

Interaction of the 2-functional group of tachysterol analogs in the vitamin D receptor ligand binding domain: X-ray co-crystallographic analysis.

Molecular Structure of the Rat Vitamin D Receptor Ligand Binding Domain Complexed with 2-Carbon-Substituted Vitamin D3Hormone Analogues and a LXXLL-Containing Coactivator Peptide†,‡

Biochemistry ◽  
2004 ◽  
Vol 43 (14) ◽  
pp. 4101-4110 ◽  
Author(s):  
Janeen L. Vanhooke ◽  
Matthew M. Benning ◽  
Cary B. Bauer ◽  
J. Wesley Pike ◽  
Hector F. DeLuca
Keyword(s):  
Molecular Structure ◽  
Vitamin D ◽  
Ligand Binding ◽  
Vitamin D Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand

scholarly journals Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by a Combination Andlysis of MD Simulations and SAXS Experiments

2017 ◽  
Vol 112 (3) ◽  
pp. 48a
Author(s):  
Yasuaki Anami ◽  
Nobutaka Shimizu ◽  
Toru Ekimoto ◽  
Daichi Egawa ◽  
Toshimasa Itoh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ligand Binding ◽  
Vitamin D Receptor ◽  
Md Simulations ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Antagonist Binding

scholarly journals Relationship between Structure and Conformational Change of the Vitamin D Receptor Ligand Binding Domain in 1α,25-Dihydroxyvitamin D3 Signaling

Molecules ◽  
2015 ◽  
Vol 20 (11) ◽  
pp. 20473-20486 ◽  
Author(s):  
Lin-Yan Wan ◽  
Yan-Qiong Zhang ◽  
Meng-Di Chen ◽  
You-Qin Du ◽  
Chang-Bai Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ligand Binding ◽  
Conformational Change ◽  
Vitamin D Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Dihydroxyvitamin D3

scholarly journals Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives

2013 ◽  
Vol 54 (8) ◽  
pp. 2206-2213 ◽  
Author(s):  
Hiroyuki Masuno ◽  
Teikichi Ikura ◽  
Daisuke Morizono ◽  
Isamu Orita ◽  
Sachiko Yamada ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ligand Binding ◽  
Crystal Structures ◽  
Vitamin D Receptor ◽  
Lithocholic Acid ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand
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