Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b01438 ◽

2018 ◽

Vol 61 (5) ◽

pp. 1969-1989 ◽

Author(s):

Chelliah Selvam ◽

Isabelle A. Lemasson ◽

Isabelle Brabet ◽

Nadia Oueslati ◽

Berin Karaman ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Group Iii ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists

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A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm901523t ◽

2010 ◽

Vol 53 (7) ◽

pp. 2797-2813 ◽

Author(s):

Chelliah Selvam ◽

Nadia Oueslati ◽

Isabelle A. Lemasson ◽

Isabelle Brabet ◽

Delphine Rigault ◽

...

Keyword(s):

Virtual Screening ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Group Iii ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists

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Synthesis and Biological Evaluation of 1-Amino-2-Phosphonomethylcyclopropanecarboxylic Acids, New Group III Metabotropic Glutamate Receptor Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm070262c ◽

2007 ◽

Vol 50 (15) ◽

pp. 3585-3595 ◽

Author(s):

Pauline Sibille ◽

Sébastien Lopez ◽

Isabelle Brabet ◽

Ornella Valenti ◽

Nadia Oueslati ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Biological Evaluation ◽

Group Iii ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists ◽

Synthesis And Biological Evaluation

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Group III Metabotropic Glutamate Receptor Agonists Selectively Suppress Excitatory Synaptic Currents in the Rat Prefrontal Cortex Induced by 5-Hydroxytryptamine2A Receptor Activation

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.107490 ◽

2006 ◽

Vol 320 (1) ◽

pp. 437-447 ◽

Author(s):

Ce Zhang ◽

Gerard J. Marek

Keyword(s):

Prefrontal Cortex ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Activation ◽

Synaptic Currents ◽

Group Iii ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists

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Group III metabotropic glutamate receptor agonists modulate high voltage-activated Ca 2+ currents in pyramidal neurons of the adult rat

Experimental Brain Research ◽

10.1007/s002210050337 ◽

1998 ◽

Vol 119 (2) ◽

pp. 237-244 ◽

Author(s):

Alessandro Stefani ◽

Francesca Spadoni ◽

Giorgio Bernardi

Keyword(s):

Glutamate Receptor ◽

High Voltage ◽

Pyramidal Neurons ◽

Metabotropic Glutamate Receptor ◽

Group Iii ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Adult Rat ◽

Glutamate Receptor Agonists

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Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease

Neuropharmacology ◽

10.1016/j.neuropharm.2012.05.026 ◽

2013 ◽

Vol 66 ◽

pp. 53-64 ◽

Author(s):

M. Amalric ◽

S. Lopez ◽

C. Goudet ◽

G. Fisone ◽

G. Battaglia ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Group Iii ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists

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Depression of monosynaptic excitation of spinal motoneurons by novel metabotropic glutamate receptor agonists

Neuroscience Research Supplements ◽

10.1016/0921-8696(92)90783-w ◽

1992 ◽

Vol 17 ◽

pp. 84

Author(s):

Michiko Ishida ◽

Tomoko Saitoh ◽

Haruhiko Shinozaki

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Spinal Motoneurons ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists ◽

Monosynaptic Excitation

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Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat

Neuropharmacology ◽

10.1016/s0028-3908(99)00257-9 ◽

2000 ◽

Vol 39 (5) ◽

pp. 903-910 ◽

Author(s):

M Pizzi ◽

M Benarese ◽

F Boroni ◽

F Goffi ◽

A Valerio ◽

...

Keyword(s):

Spinal Cord ◽

Glutamate Receptor ◽

Motor Neurons ◽

Metabotropic Glutamate Receptor ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Adult Rat ◽

Glutamate Receptor Agonists

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Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons

Journal of Neuroscience ◽

10.1523/jneurosci.1225-08.2008 ◽

2008 ◽

Vol 28 (32) ◽

pp. 8003-8013 ◽

Author(s):

I. Dumalska ◽

M. Wu ◽

E. Morozova ◽

R. Liu ◽

A. van den Pol ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Gonadotropin Releasing Hormone ◽

Releasing Hormone ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Group I ◽

Glutamate Receptor Agonists

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Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn

Neuroscience ◽

10.1016/s0306-4522(00)00269-4 ◽

2000 ◽

Vol 100 (2) ◽

pp. 393-406 ◽

Author(s):

G Gerber ◽

J Zhong ◽

D.-H Youn ◽

M Randic

Keyword(s):

Spinal Cord ◽

Synaptic Transmission ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Spinal Cord Dorsal Horn ◽

Rat Spinal Cord ◽

Group Iii ◽

Metabotropic Glutamate ◽

Spinal Cord Dorsal ◽

Glutamate Receptor Agonists

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Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists

Brain Research ◽

10.1016/s0006-8993(99)01065-3 ◽

1999 ◽

Vol 821 (2) ◽

pp. 539-545 ◽

Author(s):

Michael P Johnson ◽

Maryjo Chamberlain ◽

Gerard M Kelly

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Phosphoinositide Hydrolysis ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Group I ◽

Glutamate Receptor Agonists

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