PEG-400 as a nontoxic, green and reusable solvent was used for the synthesis of novel spiro-furo-pyridine-indoline-carbonitriles in the presence of a magnetically recoverable nanocatalyst.
A green and sustainable methodology for the synthesis of isoquinolines using Ru(ii)/PEG-400 as homogeneous recyclable catalytic system and N-tosylhydrazone, a rarely explored directing group has been reported.