Understanding the Effect of Solvent Structure on Organic Reaction Outcomes When Using Ionic Liquid/Acetonitrile Mixtures

2016 ◽  
Vol 120 (49) ◽  
pp. 12687-12699 ◽  
Author(s):  
Sinead T. Keaveney ◽  
Tamar L. Greaves ◽  
Danielle F. Kennedy ◽  
Jason B. Harper
Keyword(s):  
Ionic Liquid ◽  
Solvent Structure ◽  
Organic Reaction ◽  
Effect Of Solvent

Effect of solvent structure on electron reactivity: 1-butanol/water mixtures

1987 ◽  
Vol 91 (6) ◽  
pp. 1561-1564 ◽  
Author(s):  
Yadollah. Maham ◽  
Gordon R. Freeman
Keyword(s):  
Solvent Structure ◽  
Effect Of Solvent

Indium-Mediated Addition of 4-Bromocrotonic Acid to Aldehydes and Ketones—A Simple, High Yielding Route to α-Allyl-β-Hydroxy Carboxylic Acids

2004 ◽  
Vol 57 (2) ◽  
pp. 135 ◽  
Author(s):  
Michael C. Bowyer ◽  
Charles M. Gordon ◽  
Sarah K. Leitch ◽  
Adam McCluskey ◽  
Craig Ritchie
Keyword(s):  
Ionic Liquid ◽  
Carboxylic Acids ◽  
Simple Procedure ◽  
Effect Of Solvent ◽  
Reaction Proceeds ◽  
Aldehydes And Ketones ◽  
Hydroxy Carboxylic Acids ◽  
Ethanol Ethanol

We report a simple procedure for the indium-mediated addition of 4-bromocrotonic acid to a variety of aldehydes and ketones. In all instances the reaction proceeds exclusively with α-addition and typically in moderate to good yields (42–100%). The effect of solvent is minimal allowing a wide choice of conditions (methanol, ethanol, ethanol/water, water, tetrahydrofuran, and the ionic liquid [bmIm][BF4]).

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