Continuous-Flow Synthesis of Cationic Lipid SST-01 via Safe and Scalable Aerobic Oxidation and Reductive Amination

2020 ◽  
Vol 24 (10) ◽  
pp. 1988-1995
Author(s):  
Katsuaki Fujiwara ◽  
Haruro Ishitani ◽  
Shu̅ Kobayashi
Keyword(s):  
Continuous Flow ◽  
Reductive Amination ◽  
Aerobic Oxidation ◽  
Cationic Lipid ◽  
Flow Synthesis

scholarly journals Multigram-scale flow synthesis of the chiral key intermediate of (−)-paroxetine enabled by solvent-free heterogeneous organocatalysis

2019 ◽  
Vol 10 (48) ◽  
pp. 11141-11146 ◽  
Author(s):  
Sándor B. Ötvös ◽  
Miquel A. Pericàs ◽  
C. Oliver Kappe
Keyword(s):  
Continuous Flow ◽  
Reductive Amination ◽  
Conjugate Addition ◽  
Solvent Free ◽  
Flow Synthesis ◽  
Reduction Sequence

The continuous flow synthesis of the chiral key intermediate of (−)-paroxetine is demonstrated via a solvent-free organocatalytic conjugate addition followed by a telescoped reductive amination–lactamization–amide/ester reduction sequence.

scholarly journals Sequential α-lithiation and aerobic oxidation of an arylacetic acid - continuous-flow synthesis of cyclopentyl mandelic acid

2018 ◽  
Vol 8 (3-4) ◽  
pp. 109-116 ◽  
Author(s):  
Sonia De Angelis ◽  
Christopher A. Hone ◽  
Leonardo Degennaro ◽  
Paolo Celestini ◽  
Renzo Luisi ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Mandelic Acid ◽  
Aerobic Oxidation ◽  
Flow Synthesis

Continuous flow synthesis of the lamivudine precursor L-Menthyl Glyoxylate

2021 ◽  
Author(s):  
Lais S. D. Azevedo ◽  
Anderson R. Aguillon ◽  
Marcelo T. Lima ◽  
Raquel A. C. Leão ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

Continuous Flow Synthesis of Persistent Luminescent Chromium-Doped Zinc Gallate Nanoparticles

2021 ◽  
pp. 7067-7075
Author(s):  
Xiaojun Wei ◽  
Stephen V. Kershaw ◽  
Xiaodan Huang ◽  
Mingxia Jiao ◽  
Chau Chun Beh ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Zinc Gallate

scholarly journals C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2040
Author(s):  
Zsolt Fülöp ◽  
Péter Bana ◽  
István Greiner ◽  
János Éles
Keyword(s):  
Antipsychotic Drug ◽  
Catalytic Hydrogenation ◽  
Continuous Flow ◽  
Reductive Amination ◽  
Reduction Method ◽  
Bond Formation ◽  
Aluminum Salt ◽  
Line Extraction ◽  
Piperazine Derivative ◽  
Step Procedure

A new, continuous-flow consecutive reduction method was developed for the C-N bond formation in the synthesis of the key intermediate of the antipsychotic drug cariprazine. The two-step procedure consists of a DIBAL-H mediated selective ester reduction conducted in a novel, miniature alternating diameter reactor, followed by reductive amination using catalytic hydrogenation on 5% Pt/C. The connection of the optimized modules was accomplished using an at-line extraction to prevent precipitation of the aluminum salt byproducts.

scholarly journals Continuous flow synthesis of azoxybenzenes by reductive dimerization of nitrosobenzenes with gel‐bound catalysts

2021 ◽  
Author(s):  
Carsten J. Schmiegel ◽  
Patrik Berg ◽  
Franziska Obst ◽  
Roland Schoch ◽  
Dietmar Appelhans ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Reductive Dimerization
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