Substituent Effects on Temperature Dependence of Kinetic Isotope Effects in Hydride-Transfer Reactions of NADH/NAD+ Analogues in Solution: Reaction Center Rigidity Is the Key

Peter Maness; Shailendra Koirala; Pratichhya Adhikari; Nasim Salimraftar; Yun Lu

doi:10.1021/acs.orglett.0c02049

Substituent Effects on Temperature Dependence of Kinetic Isotope Effects in Hydride-Transfer Reactions of NADH/NAD+ Analogues in Solution: Reaction Center Rigidity Is the Key

Organic Letters ◽

10.1021/acs.orglett.0c02049 ◽

2020 ◽

Vol 22 (15) ◽

pp. 5963-5967

Author(s):

Peter Maness ◽

Shailendra Koirala ◽

Pratichhya Adhikari ◽

Nasim Salimraftar ◽

Yun Lu

Keyword(s):

Temperature Dependence ◽

Reaction Center ◽

Isotope Effects ◽

Substituent Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Transfer Reactions ◽

Kinetic Isotope ◽

Solution Reaction ◽

Hydride Transfer Reactions

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Solvent effects on the temperature dependence of the primary kinetic isotope effects for hydride transfer reactions in solution

10.1021/scimeetings.0c05537 ◽

2020 ◽

Author(s):

Pratichhya Adhikari ◽

Shailendra Koirala

Keyword(s):

Temperature Dependence ◽

Solvent Effects ◽

Isotope Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Transfer Reactions ◽

Kinetic Isotope ◽

Hydride Transfer Reactions

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Solvent effects on the temperature dependence of the primary kinetic isotope effects for hydride transfer reactions in solution

10.1021/scimeetings.0c05540 ◽

2020 ◽

Author(s):

Pratichhya Adhikari ◽

Shailendra Koirala

Keyword(s):

Temperature Dependence ◽

Solvent Effects ◽

Isotope Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Transfer Reactions ◽

Kinetic Isotope ◽

Hydride Transfer Reactions

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Solvent effects on the temperature dependence of the primary kinetic isotope effects for hydride transfer reactions in solution

10.1021/scimeetings.0c05543 ◽

2020 ◽

Author(s):

Pratichhya Adhikari ◽

Shailendra Koirala

Keyword(s):

Temperature Dependence ◽

Solvent Effects ◽

Isotope Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Transfer Reactions ◽

Kinetic Isotope ◽

Hydride Transfer Reactions

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Solvent effects on the temperature dependence of the primary kinetic isotope effects for hydride transfer reactions in solution

10.1021/scimeetings.0c05539 ◽

2020 ◽

Author(s):

Pratichhya Adhikari ◽

Shailendra Koirala

Keyword(s):

Temperature Dependence ◽

Solvent Effects ◽

Isotope Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Transfer Reactions ◽

Kinetic Isotope ◽

Hydride Transfer Reactions

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Steric Effects on the Primary Isotope Dependence of Secondary Kinetic Isotope Effects in Hydride Transfer Reactions in Solution: Caused by the Isotopically Different Tunneling Ready State Conformations?

Journal of the American Chemical Society ◽

10.1021/jacs.5b03085 ◽

2015 ◽

Vol 137 (20) ◽

pp. 6653-6661 ◽

Cited By ~ 11

Author(s):

Binita Maharjan ◽

Mahdi Raghibi Boroujeni ◽

Jonathan Lefton ◽

Ormacinda R. White ◽

Mortezaali Razzaghi ◽

...

Keyword(s):

Isotope Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Transfer Reactions ◽

Steric Effects ◽

Kinetic Isotope ◽

Hydride Transfer Reactions

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Computational Replication of the Primary Isotope Dependence of Secondary Kinetic Isotope Effects in Solution Hydride-Transfer Reactions: Supporting the Isotopically Different Tunneling Ready State Conformations

The Journal of Physical Chemistry A ◽

10.1021/acs.jpca.6b03571 ◽

2016 ◽

Vol 120 (25) ◽

pp. 4277-4284 ◽

Cited By ~ 5

Author(s):

Mortaza Derakhshani-Molayousefi ◽

Sadra Kashefolgheta ◽

James E. Eilers ◽

Yun Lu

Keyword(s):

Isotope Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Transfer Reactions ◽

Kinetic Isotope ◽

Hydride Transfer Reactions

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Prediction of Kinetic Isotope Effects for Various Hydride Transfer Reactions Using a New Kinetic Model

The Journal of Physical Chemistry A ◽

10.1021/acs.jpca.5b10135 ◽

2016 ◽

Vol 120 (11) ◽

pp. 1779-1799 ◽

Cited By ~ 18

Author(s):

Guang-Bin Shen ◽

Ke Xia ◽

Xiu-Tao Li ◽

Jun-Ling Li ◽

Yan-Hua Fu ◽

...

Keyword(s):

Kinetic Model ◽

Isotope Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Transfer Reactions ◽

Kinetic Isotope ◽

Hydride Transfer Reactions

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Temperature Dependence of the Primary Kinetic Isotope Effect in Hydride Transfer Reactions with NAD+and NADH Models

Bioorganic Chemistry ◽

10.1006/bioo.1996.1049 ◽

1997 ◽

Vol 25 (1) ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Vladimir Leskovac ◽

Svetlana Trivić ◽

Emilija Nikolić-Djorić

Keyword(s):

Temperature Dependence ◽

Isotope Effect ◽

Kinetic Isotope Effect ◽

Hydride Transfer ◽

Transfer Reactions ◽

Kinetic Isotope ◽

Hydride Transfer Reactions

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Tunnel effects in hydrogen-atom-transfer reactions as studied by the temperature dependence of the hydrogen deuterium kinetic isotope effects

The Journal of Physical Chemistry ◽

10.1021/j100290a062 ◽

1987 ◽

Vol 91 (6) ◽

pp. 1602-1606

Author(s):

Noboru. Fujisaki ◽

Amanz. Ruf ◽

Tino. Gaeumann

Keyword(s):

Hydrogen Atom ◽

Temperature Dependence ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Hydrogen Atom Transfer ◽

Transfer Reactions ◽

Atom Transfer ◽

Kinetic Isotope ◽

Hydrogen Deuterium ◽

Tunnel Effects

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Structure–Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase

Journal of the American Chemical Society ◽

10.1021/jacs.6b07028 ◽

2016 ◽

Vol 138 (44) ◽

pp. 14526-14529 ◽

Cited By ~ 7

Author(s):

Archie C. Reyes ◽

Tina L. Amyes ◽

John P. Richard

Keyword(s):

Isotope Effects ◽

Hydride Transfer ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Glycerol 3 Phosphate Dehydrogenase

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