scholarly journals Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides

2021 ◽  
Author(s):  
Roland Hellinger ◽  
Edin Muratspahić ◽  
Seema Devi ◽  
Johannes Koehbach ◽  
Mina Vasileva ◽  
...  
Keyword(s):  
Structural Motif ◽  
Cystine Knot

scholarly journals A common structural motif incorporating a cystine knot and a triple-stranded β-sheet in toxic and inhibitory polypeptides

1994 ◽  
Vol 3 (10) ◽  
pp. 1833-1839 ◽  
Author(s):  
Paul K. Pallaghy ◽  
Raymond S. Norton ◽  
Katherine J. Nielsen ◽  
David J. Craik
Keyword(s):  
Structural Motif ◽  
Cystine Knot ◽  
Β Sheet

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

1999 ◽  
Vol 294 (5) ◽  
pp. 1327-1336 ◽  
Author(s):  
David J Craik ◽  
Norelle L Daly ◽  
Trudy Bond ◽  
Clement Waine
Keyword(s):  
Structural Motif ◽  
Cystine Knot ◽  
Knotted Proteins

scholarly journals An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

1999 ◽  
Vol 96 (16) ◽  
pp. 8913-8918 ◽  
Author(s):  
J. P. Tam ◽  
Y.-A. Lu ◽  
J.-L. Yang ◽  
K.-W. Chiu
Keyword(s):  
Antimicrobial Peptides ◽  
Structural Motif ◽  
Cystine Knot ◽  
End To End

New cystine knot peptides from a marine sponge Asteropus sp.

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Jung ◽  
H Li ◽  
J Li ◽  
C Lee ◽  
W Lee ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Cystine Knot

SPEAR™: First commercialization of a cystine-knot insecticide

2016 ◽  
Author(s):  
John Sorenson
Keyword(s):  
Cystine Knot

The future of cystine-knot peptides in insecticide development

2016 ◽  
Author(s):  
Robert Kennedy
Keyword(s):  
Cystine Knot ◽  
The Future

A Chemical Perspective to the Anti-Amyloid Action of Compounds and a Nanoparticle Based Assay for Screening Amyloid Inhibitors

2020 ◽  
Author(s):  
Nidhi Gour ◽  
Bharti Koshti
Keyword(s):  
Memory Loss ◽  
Cost Effective ◽  
Structural Motif ◽  
Rapid Screening ◽  
Stacking Interactions ◽  
Aromatic Rings ◽  
Amyloid Fibers ◽  
Aromatic Stacking ◽  
Cost Effective Technique ◽  
The Brain

Aggregation of amyloid beeta 1-42 (Aβ<sub>42</sub>) peptide causes the formation of clustered deposits knows as amyloid plaques in the brain which leads to neuronal dysfunction and memory loss and associated with many neurological disorders including Alzheimer’s and Parkinson’s. Aβ<sub>42</sub> has core structural motif with phenylalanine at the 19 and 20 positions. The diphenylalanine (FF) residue plays a crucial role in the formation of amyloid fibers and serves as model peptide for studying Aβ<sub>42 </sub>aggregation. FF self-assembles to well-ordered tubular morphology via aromatic pi-pi stackings. Our studies, suggest that the aromatic rings present in the anti-amyloidogenic compounds may interact with the pi-pi stacking interactions present in the FF. Even the compounds which do not have aromatic rings, like cyclodextrin and cucurbituril show anti-amyloid property due to the binding of aromatic ring inside the guest cavity. Hence, our studies also suggest that compounds which may have a functional moiety capable of interacting with the aromatic stacking interactions might be tested for their anti-amyloidogenic properties. Further, in this manuscript, we have proposed two novel nanoparticle based assays for the rapid screening of amyloid inhibitors. In the first assay, interaction between biotin-tagged FF peptide and the streptavidin labelled gold nanoparticles (s-AuNPs) were used. In another assay, thiol-Au interactions were used to develop an assay for detection of amyloid inhibitors. It is envisaged that the proposed analytical method will provide a simple, facile and cost effective technique for the screening of amyloid inhibitors and may be of immense practical implications to find the therapeutic remedies for the diseases associated with the protein aggregation.

Journey as Structural Motif in “Song of Myself”

2007 ◽  
Vol 33 (3) ◽  
pp. 107-127
Author(s):  
장영희
Keyword(s):  
Structural Motif

Oxidative Folding of the Cystine Knot Motif in Cyclotide Proteins

2005 ◽  
Vol 12 (2) ◽  
pp. 147-152 ◽  
Author(s):  
David Craik ◽  
Norelle Daly
Keyword(s):  
Oxidative Folding ◽  
Cystine Knot
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