SPEAR™: First commercialization of a cystine-knot insecticide

2016 ◽  
Author(s):  
John Sorenson
Keyword(s):  
Cystine Knot

New cystine knot peptides from a marine sponge Asteropus sp.

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Jung ◽  
H Li ◽  
J Li ◽  
C Lee ◽  
W Lee ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Cystine Knot

Oxidative Folding of the Cystine Knot Motif in Cyclotide Proteins

2005 ◽  
Vol 12 (2) ◽  
pp. 147-152 ◽  
Author(s):  
David Craik ◽  
Norelle Daly
Keyword(s):  
Oxidative Folding ◽  
Cystine Knot

Design, Pharmacology, and NMR Structure of a Minimized Cystine Knot with Agouti-Related Protein Activity†

Biochemistry ◽  
2002 ◽  
Vol 41 (24) ◽  
pp. 7565-7572 ◽  
Author(s):  
Pilgrim J. Jackson ◽  
Joseph C. McNulty ◽  
Ying-Kui Yang ◽  
Darren A. Thompson ◽  
Biaoxin Chai ◽  
...  
Keyword(s):  
Nmr Structure ◽  
Related Protein ◽  
Protein Activity ◽  
Cystine Knot ◽  
Agouti Related Protein

High level expression of the Drosophila Toll receptor ectodomain and crystallization of its complex with the morphogen Spätzle

2013 ◽  
Vol 394 (8) ◽  
pp. 1091-1096 ◽  
Author(s):  
Marco Stelter ◽  
Uwe Fandrich ◽  
Kati Franzke ◽  
Angelika Schierhorn ◽  
Constanze Breithaupt ◽  
...  
Keyword(s):  
Immune Response ◽  
High Level Expression ◽  
Receptor Ligand ◽  
High Affinity ◽  
Cystine Knot ◽  
Toll Receptor ◽  
Cystine Knot Protein ◽  
High Yields ◽  
High Level ◽  
Affinity Interaction

Abstract Drosophila Toll receptors are involved in embryonic development and in the immune response of adult flies. In both processes, the Toll receptor ligand is the NGF-like cystine knot protein Spätzle. Here we present the expression of Toll receptor ectodomain in Schneider cells at high yields and demonstrate a high affinity interaction with the refolded and trypsin-processed Spätzle cystine knot domain dimer. Poorly and anisotropically diffracting crystals of the complex could be improved by deglycosylation and dehydration, paving the way for structural analyses of the Toll-Spätzle interaction.

scholarly journals RhNGF slow unfolding is not due to proline isomerization: Possibility of a cystine knot loop-threading mechanism

1996 ◽  
Vol 5 (8) ◽  
pp. 1554-1566 ◽  
Author(s):  
Linda R. de Young ◽  
Louis E. Burton ◽  
Jun Liu ◽  
Michael F. Powell ◽  
Charles H. Schmelzer ◽  
...  
Keyword(s):  
Proline Isomerization ◽  
Cystine Knot

scholarly journals Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold

2020 ◽  
Vol 15 (6) ◽  
pp. 1650-1661 ◽  
Author(s):  
Huawu Yin ◽  
Yen-Hua Huang ◽  
Kirsten Deprey ◽  
Nicholas D. Condon ◽  
Joshua A. Kritzer ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Cystine Knot ◽  
Cytosolic Delivery
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