scholarly journals MetEx, a Metabolomics Explorer Application for Natural Product Discovery

2021 ◽  
Author(s):  
Brett C. Covington ◽  
Mohammad R. Seyedsayamdost
Keyword(s):  
Natural Product ◽  
Natural Product Discovery

Expediting natural product discovery through genomics

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
B Moore
Keyword(s):  
Natural Product ◽  
Natural Product Discovery

Application of a simple bioactivity profiling strategy to natural product discovery from endophytes of marine macroalgae

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
AJ Flewelling ◽  
JA Johnson ◽  
CA Gray
Keyword(s):  
Natural Product ◽  
Marine Macroalgae ◽  
Natural Product Discovery

scholarly journals Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches

2021 ◽  
Author(s):  
Mehdi A. Beniddir ◽  
Kyo Bin Kang ◽  
Grégory Genta-Jouve ◽  
Florian Huber ◽  
Simon Rogers ◽  
...  
Keyword(s):  
Natural Product ◽  
Large Scale ◽  
Scale Analysis ◽  
Computational Tools ◽  
Natural Product Discovery ◽  
Large Scale Analysis ◽  
Metabolite Annotation

This review highlights the key computational tools and emerging strategies for metabolite annotation, and discusses how these advances will enable integrated large-scale analysis to accelerate natural product discovery.

ChemInform Abstract: Genome Mining for Novel Natural Product Discovery

ChemInform ◽  
2008 ◽  
Vol 39 (29) ◽  
Author(s):  
Gregory L. Challis
Keyword(s):  
Natural Product ◽  
Genome Mining ◽  
Natural Product Discovery

scholarly journals The Tripod for Bacterial Natural Product Discovery: Genome Mining, Silent Pathway Induction, and Mass Spectrometry-Based Molecular Networking

mSystems ◽  
2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Daniela B. B. Trivella ◽  
Rafael de Felicio
Keyword(s):  
Mass Spectrometry ◽  
Natural Products ◽  
Natural Product ◽  
Biosynthetic Pathway ◽  
Genome Mining ◽  
Chemical Compounds ◽  
Gene Clusters ◽  
Tandem Mass ◽  
Molecular Networking ◽  
Natural Product Discovery

ABSTRACT Natural products are the richest source of chemical compounds for drug discovery. Particularly, bacterial secondary metabolites are in the spotlight due to advances in genome sequencing and mining, as well as for the potential of biosynthetic pathway manipulation to awake silent (cryptic) gene clusters under laboratory cultivation. Further progress in compound detection, such as the development of the tandem mass spectrometry (MS/MS) molecular networking approach, has contributed to the discovery of novel bacterial natural products. The latter can be applied directly to bacterial crude extracts for identifying and dereplicating known compounds, therefore assisting the prioritization of extracts containing novel natural products, for example. In our opinion, these three approaches—genome mining, silent pathway induction, and MS-based molecular networking—compose the tripod for modern bacterial natural product discovery and will be discussed in this perspective.

Natural product discovery through microbial genome mining

2021 ◽  
Vol 60 ◽  
pp. 47-54
Author(s):  
Emma Kenshole ◽  
Marion Herisse ◽  
Michael Michael ◽  
Sacha J. Pidot
Keyword(s):  
Natural Product ◽  
Genome Mining ◽  
Microbial Genome ◽  
Natural Product Discovery

Biodiversity of Actinomycetes Associated with Caribbean Sponges and Their Potential for Natural Product Discovery

2013 ◽  
Vol 15 (4) ◽  
pp. 413-424 ◽  
Author(s):  
Jan Vicente ◽  
Allison Stewart ◽  
Bongkeun Song ◽  
Russell T. Hill ◽  
Jeffrey L. Wright
Keyword(s):  
Natural Product ◽  
Natural Product Discovery

scholarly journals Natural Product Discovery by Direct Analysis in Real Time Mass Spectrometry

2019 ◽  
Vol 8 (2) ◽  
pp. S0081-S0081
Author(s):  
Joanne Y. Yew
Keyword(s):  
Mass Spectrometry ◽  
Natural Product ◽  
Real Time ◽  
Direct Analysis ◽  
Natural Product Discovery

scholarly journals Genomic Assemblies of Members of Burkholderia and Related Genera as a Resource for Natural Product Discovery

2020 ◽  
Vol 9 (42) ◽  
Author(s):  
Alex J. Mullins ◽  
Cerith Jones ◽  
Matthew J. Bull ◽  
Gordon Webster ◽  
Julian Parkhill ◽  
...  
Keyword(s):  
Natural Product ◽  
Genome Mining ◽  
Genomic Analysis ◽  
Gene Clusters ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Natural Product Discovery

ABSTRACT The genomes of 450 members of Burkholderiaceae, isolated from clinical and environmental sources, were sequenced and assembled as a resource for genome mining. Genomic analysis of the collection has enabled the identification of multiple metabolites and their biosynthetic gene clusters, including the antibiotics gladiolin, icosalide A, enacyloxin, and cepacin A.

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