High Selectivity and Sensitivity of Oligomeric p-Phenylene Ethynylenes for Detecting Fibrillar and Prefibrillar Amyloid Protein Aggregates

2019 ◽  
Vol 10 (3) ◽  
pp. 1813-1825 ◽  
Author(s):  
Adeline M. Fanni ◽  
Florencia A. Monge ◽  
Chia-Yu Lin ◽  
Arjun Thapa ◽  
Kiran Bhaskar ◽  
...  
Keyword(s):  
High Selectivity ◽  
Protein Aggregates ◽  
Amyloid Protein ◽  
Phenylene Ethynylenes

scholarly journals High Selectivity and Sensitivity of Oligomeric P-Phenylene Ethynylenes for Detecting Amyloid Proteins In-Vitro

2018 ◽  
Vol 114 (3) ◽  
pp. 358a
Author(s):  
Adeline M. Fanni ◽  
Florencia A. Monge ◽  
Arjun Thapa ◽  
David G. Whitten ◽  
Eva Y. Chi
Keyword(s):  
High Selectivity ◽  
Amyloid Proteins ◽  
Phenylene Ethynylenes

Colloidal-like aggregation of a functional amyloid protein

2020 ◽  
Vol 22 (40) ◽  
pp. 23286-23294
Author(s):  
David N. Azulay ◽  
Mnar Ghrayeb ◽  
Ilanit Bensimhon Ktorza ◽  
Ido Nir ◽  
Rinad Nasser ◽  
...  
Keyword(s):  
Protein Aggregates ◽  
Amyloid Protein ◽  
Functional Amyloid ◽  
Acidic Conditions

TasA, a bacterial functional amyloid protein, aggregates in a colloidal – like mechanism upon exposure to acidic conditions.

scholarly journals Prefibrillar Amyloid Protein Aggregates Share Common Features of Cytotoxicity

2004 ◽  
Vol 279 (30) ◽  
pp. 31374-31382 ◽  
Author(s):  
Monica Bucciantini ◽  
Giulia Calloni ◽  
Fabrizio Chiti ◽  
Lucia Formigli ◽  
Daniele Nosi ◽  
...  
Keyword(s):  
Protein Aggregates ◽  
Amyloid Protein ◽  
Common Features

Disassembling and degradation of amyloid protein aggregates based on gold nanoparticle-modified g-C3N4

2020 ◽  
Vol 192 ◽  
pp. 111051 ◽  
Author(s):  
Jie Wang ◽  
Yonghai Feng ◽  
Xiaohua Tian ◽  
Chenglong Li ◽  
Lei Liu
Keyword(s):  
Gold Nanoparticle ◽  
Protein Aggregates ◽  
Amyloid Protein

Gold nanoparticles for selective and remote heating of β-amyloid protein aggregates

2007 ◽  
Vol 27 (5-8) ◽  
pp. 1236-1240 ◽  
Author(s):  
Neus G. Bastus ◽  
Marcelo J. Kogan ◽  
Roger Amigo ◽  
Dolors Grillo-Bosch ◽  
Eyleen Araya ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Protein Aggregates ◽  
Amyloid Protein ◽  
Β Amyloid

scholarly journals Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

2016 ◽  
Vol 7 (3) ◽  
pp. 399-406 ◽  
Author(s):  
Mathew H. Horrocks ◽  
Steven F. Lee ◽  
Sonia Gandhi ◽  
Nadia K. Magdalinou ◽  
Serene W. Chen ◽  
...  
Keyword(s):  
Single Molecule ◽  
Protein Aggregates ◽  
Single Molecule Imaging ◽  
Amyloid Protein

scholarly journals 11C and 18F Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates

2016 ◽  
Vol 7 (4) ◽  
pp. 368-373 ◽  
Author(s):  
Patrik Nordeman ◽  
Leif B. G. Johansson ◽  
Marcus Bäck ◽  
Sergio Estrada ◽  
Håkan Hall ◽  
...  
Keyword(s):  
Protein Aggregates ◽  
Amyloid Protein

scholarly journals Mapping the binding site topology of amyloid protein aggregates using multivalent ligands

2021 ◽  
Author(s):  
Elena Sanna ◽  
Margarida Rodrigues ◽  
Steven G. Fagan ◽  
Timothy S. Chisholm ◽  
Klara Kulenkampff ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Binding Site ◽  
Protein Aggregates ◽  
Amyloid Protein ◽  
Multivalent Ligands ◽  
Affinity Reagents ◽  
High Affinity ◽  
Head Groups ◽  
Powerful Approach

Multivalent ligands offer a powerful approach to obtain high affinity reagents to bind the aggregates that form in neurodegenerative disease. Selectivity for different proteins was achieved by using different linkers to connect the head groups.

Amyloid protein aggregates: new clients for mitochondrial energy production in the brain?

FEBS Journal ◽  
2020 ◽  
Vol 287 (16) ◽  
pp. 3386-3395 ◽  
Author(s):  
Senthilkumar Sivanesan ◽  
Edwin Chang ◽  
Mathew D. Howell ◽  
Jayakumar Rajadas
Keyword(s):  
Energy Production ◽  
Protein Aggregates ◽  
Amyloid Protein ◽  
Mitochondrial Energy Production ◽  
The Brain
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