Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.1c00363 ◽

2021 ◽

Author(s):

Matthew Spock ◽

Trever R. Carter ◽

Katrina A. Bollinger ◽

Changho Han ◽

Logan A. Baker ◽

...

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine ◽

Orally Bioavailable

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ChemInform Abstract: Discovery of (3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo [3.2.1]octane Bromide as an Efficacious Inhaled Muscarinic Acetylcholine Receptor Antagonist for the Treatment of COPD.

10.1002/chin.200951215 ◽

2009 ◽

Vol 40 (51) ◽

pp. no-no

Author(s):

Zehong Wan ◽

et al. et al.

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine

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Migrastatin Acts as a Muscarinic Acetylcholine Receptor Antagonist

The Journal of Antibiotics ◽

10.1038/ja.2006.91 ◽

2006 ◽

Vol 59 (11) ◽

pp. 685-692 ◽

Author(s):

Koichi Nakae ◽

Yoshio Nishimura ◽

Syunichi Ohba ◽

Yuzuru Akamatsu

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine

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In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist /β2-adrenoceptor agonist (MABA) compound in neutrophils from COPD patients

PLoS ONE ◽

10.1371/journal.pone.0210188 ◽

2019 ◽

Vol 14 (1) ◽

pp. e0210188 ◽

Author(s):

Javier Milara ◽

Sonia Contreras ◽

Alfredo de Diego ◽

Marta Calbet ◽

Mònica Aparici ◽

...

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine ◽

Copd Patients ◽

Adrenoceptor Agonist ◽

Anti Inflammatory

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Positron labeled muscarinic acetylcholine receptor antagonist: 2- and 4-[18F]fluorodexetimide. Syntheses and biodistribution

International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology ◽

10.1016/0883-2897(91)90086-z ◽

1991 ◽

Vol 18 (2) ◽

pp. 247-252 ◽

Author(s):

Dah-Ren Hwang ◽

Carmen S. Dence ◽

Zoe Ann McKinnon ◽

Carla J. Mathias ◽

Michael J. Welch

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine

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Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2011.01.043 ◽

2011 ◽

Vol 21 (5) ◽

pp. 1354-1358 ◽

Author(s):

Adam D. Hughes ◽

Kay H. Chin ◽

Sarah L. Dunham ◽

Jeffrey R. Jasper ◽

Kristin E. King ◽

...

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine ◽

Adrenoceptor Agonist ◽

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Treatment with a muscarinic acetylcholine receptor antagonist impairs the acquisition of conditioned reward learning in rats

Neuroscience Letters ◽

10.1016/j.neulet.2015.12.064 ◽

2016 ◽

Vol 614 ◽

pp. 95-98 ◽

Author(s):

R. Nisanov ◽

E. Galaj ◽

R. Ranaldi

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Reward Learning ◽

Conditioned Reward ◽

Muscarinic Acetylcholine

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Synthesis, in vivo biodistribution and dosimetry of [11C]N-Methylpiperidyl benzilate ([11C]NMPB), a muscarinic acetylcholine receptor antagonist

Nuclear Medicine and Biology ◽

10.1016/0969-8051(94)00082-u ◽

1995 ◽

Vol 22 (1) ◽

pp. 13-17 ◽

Author(s):

G.Keith Mulholland ◽

Michael R. Kilbourn ◽

Phillip Sherman ◽

James E. Carey ◽

Kirk A. Frey ◽

...

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine ◽

In Vivo Biodistribution

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The oxime HGG-12 as a muscarinic acetylcholine receptor antagonist without intrinsic activity in cardiac membranes

Archives of Toxicology ◽

10.1007/bf01977367 ◽

1991 ◽

Vol 65 (6) ◽

pp. 518-523 ◽

Author(s):

C. Reithmann ◽

H. -J. Berger ◽

G. Hilf ◽

K. Werdan

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Intrinsic Activity ◽

Muscarinic Acetylcholine ◽

Cardiac Membranes ◽

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Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.07.006 ◽

2009 ◽

Vol 19 (16) ◽

pp. 4560-4562 ◽

Author(s):

Zehong Wan ◽

Dramane I. Laine ◽

Hongxing Yan ◽

Chongjie Zhu ◽

Katherine L. Widdowson ◽

...

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine

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Combined treatment with a 5HT1A receptor agonist and a muscarinic acetylcholine receptor antagonist disrupts water maze navigation behavior

Psychopharmacology ◽

10.1007/bf02246088 ◽

1995 ◽

Vol 122 (2) ◽

pp. 137-146 ◽

Author(s):

M. Riekkinen ◽

J. Sirviö ◽

T. Toivanen ◽

P. Riekkinen

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Combined Treatment ◽

Muscarinic Acetylcholine Receptor ◽

5Ht1a Receptor ◽

Muscarinic Acetylcholine ◽

Maze Navigation

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