scholarly journals Multivalent, Soluble Nano-Self Peptides Increase Phagocytosis of Antibody-Opsonized Targets while Suppressing “Self” Signaling

ACS Nano ◽  
2020 ◽  
Vol 14 (11) ◽  
pp. 15083-15093
Author(s):  
AbdelAziz R. Jalil ◽  
Brandon H. Hayes ◽  
Jason C. Andrechak ◽  
Yuntao Xia ◽  
David M. Chenoweth ◽  
...  
Keyword(s):  
Self Peptides

scholarly journals Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Anna Cebula ◽  
Michal Kuczma ◽  
Edyta Szurek ◽  
Maciej Pietrzak ◽  
Natasha Savage ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell Receptors ◽  
Negative Selection ◽  
Regulatory Cells ◽  
Central Tolerance ◽  
Therapeutic Advantage ◽  
Autoreactive T Cell ◽  
Peptide Complexes ◽  
Self Peptides

Abstract Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an unknown number of autoreactive CD4+Foxp3− T cells escape negative selection and in the periphery require continuous suppression by CD4+Foxp3+ regulatory cells (Tregs). Here, we compare immune repertoires of Treg-deficient and Treg-sufficient mice to find Tregs continuously constraining one-third of mature CD4+Foxp3− cells from converting to pathogenic effectors in healthy mice. These dormant pathogenic clones frequently express TCRs activatable by ubiquitous autoantigens presented by class II MHCs on conventional dendritic cells, including self-peptides that select them in the thymus. Our data thus suggest that identification of most potentially autoreactive CD4+ T cells in the peripheral repertoire is critical to harness or redirect these cells for therapeutic advantage.

scholarly journals Rare, Structurally Homologous Self-Peptides Promote Thymocyte Positive Selection

Immunity ◽  
2002 ◽  
Vol 17 (2) ◽  
pp. 131-142 ◽  
Author(s):  
Fabio R Santori ◽  
William C Kieper ◽  
Stuart M Brown ◽  
Yun Lu ◽  
Thomas A Neubert ◽  
...  
Keyword(s):  
Positive Selection ◽  
Self Peptides

scholarly journals Conformational Dimorphism of Self-peptides and Molecular Mimicry in a Disease-associated HLA-B27 Subtype

2005 ◽  
Vol 281 (4) ◽  
pp. 2306-2316 ◽  
Author(s):  
Christine Rückert ◽  
Maria Teresa Fiorillo ◽  
Bernhard Loll ◽  
Roberto Moretti ◽  
Jacek Biesiadka ◽  
...  
Keyword(s):  
Molecular Mimicry ◽  
Hla B27 ◽  
Self Peptides

T cell responses to citrullinated self-peptides in patients with rheumatoid arthritis

2013 ◽  
Vol 33 (9) ◽  
pp. 2359-2363 ◽  
Author(s):  
Amita Aggarwal ◽  
Rajni Srivastava ◽  
Suraksha Agrawal
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Self Peptides

scholarly journals Presentation of self peptides by dendritic cells. Possible implications for the pathogenesis of rheumatoid arthritis

1996 ◽  
Vol 39 (2) ◽  
pp. 183-190 ◽  
Author(s):  
Ranjeny Thomas ◽  
Peter E. Lipsky
Keyword(s):  
Rheumatoid Arthritis ◽  
Dendritic Cells ◽  
Presentation Of Self ◽  
Self Peptides

Generation of Self-Peptides to Treat Systemic Lupus Erythematosus

2014 ◽  
pp. 173-192 ◽  
Author(s):  
Jean-Paul Briand ◽  
Nicolas Schall ◽  
Sylviane Muller
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Self Peptides

Prion Protein Self-Peptides

Prion Biology ◽  
2013 ◽  
Author(s):  
Alan Rigter ◽  
Jan Priem ◽  
Drophatie Timmers-Parohi ◽  
Jan Langeveld ◽  
Fred van Zijderveld ◽  
...  
Keyword(s):  
Prion Protein ◽  
Self Peptides

scholarly journals Prion protein self-peptides modulate prion interactions and conversion

2009 ◽  
Vol 10 (1) ◽  
pp. 29 ◽  
Author(s):  
Alan Rigter ◽  
Jan Priem ◽  
Drophatie Timmers-Parohi ◽  
Jan PM Langeveld ◽  
Fred G van Zijderveld ◽  
...  
Keyword(s):  
Prion Protein ◽  
Self Peptides
Sign in / Sign up

Export Citation Format

Share Document