Synergistic Immunostimulation through the Dual Activation of Toll-like Receptor 3/9 with Spherical Nucleic Acids

ACS Nano ◽  
2021 ◽  
Author(s):  
Ziyin N. Huang ◽  
Cassandra E. Callmann ◽  
Lisa E. Cole ◽  
Shuya Wang ◽  
Chad A. Mirkin
Keyword(s):  
Nucleic Acids ◽  
Toll Like Receptor ◽  
Dual Activation ◽  
Spherical Nucleic Acids

scholarly journals Dual Toll-Like Receptor Targeting Liposomal Spherical Nucleic Acids

2019 ◽  
Vol 30 (3) ◽  
pp. 944-951 ◽  
Author(s):  
Jennifer R. Ferrer ◽  
Jason A. Wertheim ◽  
Chad A. Mirkin
Keyword(s):  
Nucleic Acids ◽  
Toll Like Receptor ◽  
Receptor Targeting ◽  
Spherical Nucleic Acids

scholarly journals Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation

2021 ◽  
Vol 143 (3) ◽  
pp. 1296-1300
Author(s):  
Yang Fang ◽  
Xueguang Lu ◽  
Dali Wang ◽  
Jiansong Cai ◽  
Yuyan Wang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Topical Treatment ◽  
Spherical Nucleic Acids

scholarly journals Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core

2021 ◽  
Author(s):  
Vijay Gulumkar ◽  
Antti Äärelä ◽  
Olli Moisio ◽  
Jani Rahkila ◽  
Ville Tähtinen ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Buckminster Fullerene ◽  
Spherical Nucleic Acids

scholarly journals Gene Regulation Using Spherical Nucleic Acids to Treat Skin Disorders

2020 ◽  
Vol 13 (11) ◽  
pp. 360
Author(s):  
Thomas R. Holmes ◽  
Amy S. Paller
Keyword(s):  
Nucleic Acids ◽  
Mouse Models ◽  
Phase 1 ◽  
Diabetic Mouse ◽  
Intratumoral Injection ◽  
Skin Disorders ◽  
Ganglioside Gm3 ◽  
Human Trials ◽  
Accelerate Wound Healing ◽  
Spherical Nucleic Acids

Spherical nucleic acids (SNAs) are nanostructures consisting of nucleic acids in a spherical configuration, often around a nanoparticle core. SNAs are advantageous as gene-regulating agents compared to conventional gene therapy owing to their low toxicity, enhanced stability, uptake by virtually any cell, and ability to penetrate the epidermal barrier. In this review we: (i) describe the production, structure and properties of SNAs; (ii) detail the mechanism of SNA uptake in keratinocytes, regulated by scavenger receptors; and (iii) report how SNAs have been topically applied and intralesionally injected for skin disorders. Specialized SNAs called nanoflares can be topically applied for gene-based diagnosis (scar vs. normal tissue). Topical SNAs directed against TNFα and interleukin-17A receptor reversed psoriasis-like disease in mouse models and have been tested in Phase 1 human trials. Furthermore, SNAs targeting ganglioside GM3 synthase accelerate wound healing in diabetic mouse models. Most recently, SNAs targeting toll-like receptor 9 are being used in Phase 2 human trials via intratumoral injection to induce immune responses in Merkel cell and cutaneous squamous cell carcinoma. Overall, SNAs are a valuable tool in bench-top and clinical research, and their advantageous properties, including penetration into the epidermis after topical delivery, provide new opportunities for targeted therapies.

Spherical nucleic acids start rolling

Science ◽  
2015 ◽  
Vol 349 (6253) ◽  
pp. 1150-1151 ◽  
Author(s):  
Robert F. Service
Keyword(s):  
Nucleic Acids ◽  
Spherical Nucleic Acids

Modular Combination of Proteolysis-Responsive Transcription and Spherical Nucleic Acids for Smartphone-Based Colorimetric Detection of Protease Biomarkers

2021 ◽  
Vol 93 (7) ◽  
pp. 3517-3525
Author(s):  
Fang Liu ◽  
Ru Chen ◽  
Wenlu Song ◽  
Liangwen Li ◽  
Chunyang Lei ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Colorimetric Detection ◽  
Spherical Nucleic Acids

Poly-adenine-mediated spherical nucleic acids for strand displacement-based DNA/RNA detection

2019 ◽  
Vol 127 ◽  
pp. 85-91 ◽  
Author(s):  
Lu Wang ◽  
Huan Zhang ◽  
Chenguang Wang ◽  
Yi Xu ◽  
Jing Su ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Strand Displacement ◽  
Rna Detection ◽  
Displacement Based ◽  
Spherical Nucleic Acids

scholarly journals Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine

Aggregate ◽  
2021 ◽  
Author(s):  
Yangmeihui Song ◽  
Wenyu Song ◽  
Xiaoli Lan ◽  
Weibo Cai ◽  
Dawei Jiang
Keyword(s):  
Nucleic Acids ◽  
Spherical Nucleic Acids

scholarly journals Spherical nucleic acids: A whole new ball game

2013 ◽  
Vol 110 (33) ◽  
pp. 13231-13233 ◽  
Author(s):  
S. C. P. Williams
Keyword(s):  
Nucleic Acids ◽  
Ball Game ◽  
Spherical Nucleic Acids
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