scholarly journals Mutagenesis Reveals an Unusual Combination of Guanines in RNA G-Quadruplex Formation

ACS Omega ◽  
2017 ◽  
Vol 2 (8) ◽  
pp. 4790-4799
Author(s):  
Prachi Agarwala ◽  
Gargi Pal ◽  
Satyaprakash Pandey ◽  
Souvik Maiti
Keyword(s):  
G Quadruplex ◽  
Unusual Combination ◽  
Quadruplex Formation

scholarly journals DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation

2013 ◽  
Vol 41 (22) ◽  
pp. 10323-10333 ◽  
Author(s):  
Justin D. Lormand ◽  
Noah Buncher ◽  
Connor T. Murphy ◽  
Parminder Kaur ◽  
Marietta Y. Lee ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Δ ◽  
G Quadruplex ◽  
Quadruplex Formation ◽  
Lagging Strand

scholarly journals TGF‐β‐induced fibrotic stress increases G‐quadruplex formation in human fibroblasts

FEBS Letters ◽  
2019 ◽  
Vol 593 (22) ◽  
pp. 3149-3161 ◽  
Author(s):  
Priyanka Toshniwal ◽  
Michelle Nguyen ◽  
Aurore Guédin ◽  
Helena Viola ◽  
Diwei Ho ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
G Quadruplex ◽  
Quadruplex Formation

TT Dimerization and Its Effect on Human Telomere G-Quadruplex Formation

2015 ◽  
Vol 36 (6) ◽  
pp. 1729-1732
Author(s):  
In Sun Kim ◽  
Young Jun Seo
Keyword(s):  
G Quadruplex ◽  
Quadruplex Formation ◽  
Human Telomere

Inhibition of Protein Synthesis Through RNA-Based Tandem G-Quadruplex Formation

2021 ◽  
Author(s):  
Masaki Hagihara
Keyword(s):  
Protein Synthesis ◽  
Reverse Transcriptase ◽  
Repeat Sequences ◽  
Guanine Quadruplex ◽  
G Quadruplex ◽  
Inhibition Of Protein Synthesis ◽  
Quadruplex Formation

Tandem guanine repeat sequences can adopt guanine quadruplex (G-quadruplex) structures and consecutive guanine repeat sequences can potentially afford multiple G-quadruplex structures. By using a reverse transcriptase stop assay and biophysical...

scholarly journals Structure and Stability of a Dimeric G-Quadruplex Formed by Cyclic Oligonucleotides

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Joan Casals ◽  
Júlia Viladoms ◽  
Enrique Pedroso ◽  
Carlos González
Keyword(s):  
Telomeric Repeat ◽  
High Melting ◽  
Structure And Stability ◽  
Dimeric Structure ◽  
Nmr Data ◽  
High Melting Temperature ◽  
Sodium Nmr ◽  
G Quadruplex ◽  
Global Topology ◽  
Quadruplex Formation

We have studied the structure and stability of the cyclic dodecamer d<pGGGTTAGGGTTA>, containing two copies of the human telomeric repeat. In the presence of sodium, NMR data are consistent with a dimeric structure of the molecule in which two cycles self-associate forming a quadruplex with three guanine tetrads connected by edgewise loops. The two macrocycles are arranged in a parallel way, and the dimeric structure exhibits a high melting temperature. These results indicate that cyclization of the phosphodiester chain does not prevent quadruplex formation, although it affects the global topology of the quadruplex.

scholarly journals A Minimal Sequence for Left‐Handed G‐Quadruplex Formation

2019 ◽  
Vol 58 (8) ◽  
pp. 2331-2335 ◽  
Author(s):  
Blaž Bakalar ◽  
Brahim Heddi ◽  
Emmanuelle Schmitt ◽  
Yves Mechulam ◽  
Anh Tuân Phan
Keyword(s):  
Left Handed ◽  
G Quadruplex ◽  
Quadruplex Formation ◽  
Minimal Sequence

scholarly journals A Minimal Sequence for Left-Handed G-Quadruplex Formation

2019 ◽  
Vol 131 (8) ◽  
pp. 2353-2357 ◽  
Author(s):  
Blaž Bakalar ◽  
Brahim Heddi ◽  
Emmanuelle Schmitt ◽  
Yves Mechulam ◽  
Anh Tuân Phan
Keyword(s):  
Left Handed ◽  
G Quadruplex ◽  
Quadruplex Formation ◽  
Minimal Sequence

scholarly journals Impact of a Single Nucleotide Change or Non-Nucleoside Modifications in G-Rich Region on the Quadruplex–Duplex Hybrid Formation

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1236
Author(s):  
Dorota Gudanis ◽  
Karolina Zielińska ◽  
Daniel Baranowski ◽  
Ryszard Kierzek ◽  
Piotr Kozłowski ◽  
...  
Keyword(s):  
Target Sequence ◽  
Rich Region ◽  
Rna Sequences ◽  
Single Nucleotide ◽  
Alternative Structures ◽  
Single Nucleotide Change ◽  
G Quadruplex ◽  
Quadruplex Formation ◽  
Target Rna ◽  
Insight Into

In this paper, a method to discriminate between two target RNA sequences that differ by one nucleotide only is presented. The method relies on the formation of alternative structures, i.e., quadruplex–duplex hybrid (QDH) and duplex with dangling ends (Dss), after hybridization of DNA or RNA G-rich oligonucleotides with target sequences containing 5′–GGGCUGG–3′ or 5′–GGGCGGG–3′ fragments. Using biophysical methods, we studied the effect of oligonucleotide types (DNA, RNA), non-nucleotide modifications (aliphatic linkers or abasic), and covalently attached G4 ligand on the ability of G-rich oligonucleotides to assemble a G-quadruplex motif. We demonstrated that all examined non-nucleotide modifications could mimic the external loops in the G-quadruplex domain of QDH structures without affecting their stability. Additionally, some modifications, in particular the presence of two abasic residues in the G-rich oligonucleotide, can induce the formation of non-canonical QDH instead of the Dss structure upon hybridization to a target sequence containing the GGGCUGG motif. Our results offer new insight into the sequential requirements for the formation of G-quadruplexes and provide important data on the effects of non-nucleotide modifications on G-quadruplex formation.

scholarly journals Selective Interactions with Various G-Quadruplex DNA Forming Sequences by Berberine and Palmatine Analogues

2018 ◽  
Author(s):  
Marco Franceschin ◽  
Lorenzo Cianni ◽  
Massimo Pitorri ◽  
Emanuela Micheli ◽  
Stefano Cacchione ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Natural Compounds ◽  
Side Chains ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Quadruplex Formation ◽  
Selective Interactions

In this article/review, the selective interactions of several berberine and palmatine derivatives with various DNA G-quadruplex structures are reported. These derivatives were constructed starting from two natural compounds, berberine and palamatine, through specific synthetic passages following two different schemes for each of them and using several substituents. The details of these synthesis are also described. Indeed, the study of the interactions of these derivative compounds with various G-quadruplex forming sequences was carried out by means of various structural and biochemical techniques. The results show that the presence of suitable side chains are very useful to improve the interaction of the ligands with G-quadruplex structures. Thus, since G-quadruplex formation is promoted by these compounds, which have never been reported before, these may be tested as potential anticancer drugs.

scholarly journals The effects of DNA supercoiling on G-quadruplex formation

2017 ◽  
Vol 45 (21) ◽  
pp. 12069-12079 ◽  
Author(s):  
Doreen A.T. Sekibo ◽  
Keith R. Fox
Keyword(s):  
Dna Supercoiling ◽  
G Quadruplex ◽  
Quadruplex Formation
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