scholarly journals Asymmetric Synthesis of Spirocyclopentane Oxindoles Containing Four Consecutive Stereocenters and Quaternary α-Nitro Esters via Organocatalytic Enantioselective Michael–Michael Cascade Reactions

ACS Omega ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 655-667 ◽  
Author(s):  
Prakash D. Chaudhari ◽  
Bor-Cherng Hong ◽  
Chao-Lin Wen ◽  
Gene-Hsiang Lee
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reactions ◽  
Nitro Esters

Asymmetric Synthesis of Heterocyclic γ‐Amino‐Acid and Diamine Derivatives by Three‐Component Radical Cascade Reactions

2019 ◽  
Vol 131 (44) ◽  
pp. 15950-15954 ◽  
Author(s):  
Danqing Zheng ◽  
Armido Studer
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Cascade Reactions ◽  
Radical Cascade

Chiral-Squaramide-Catalyzed Sulfa-Michael/Aldol Cascade Reactions for Asymmetric Synthesis of Spirothiochromanones

2015 ◽  
Vol 4 (8) ◽  
pp. 778-787 ◽  
Author(s):  
Bo-Liang Zhao ◽  
Da-Ming Du
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reactions

ChemInform Abstract: Asymmetric Synthesis of Cyclohexane-Fused Drug-Like Spirocyclic Scaffolds Containing Six Contiguous Stereogenic Centers via Organocatalytic Cascade Reactions.

ChemInform ◽  
2015 ◽  
Vol 46 (26) ◽  
pp. no-no
Author(s):  
Bo Han ◽  
Wei Huang ◽  
Wen Ren ◽  
Gu He ◽  
Jin-hui Wang ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reactions ◽  
Stereogenic Centers

scholarly journals Asymmetric synthesis of 2,5-dissubstituded pyrrolidines through cascade reactions

2020 ◽  
Author(s):  
Paulo Gabriel Massayuki Miyake Nakaya ◽  
Anita Jocelyne Marsaioli ◽  
Fábio Domingues Nasário
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reactions

Asymmetric Organocatalytic Syntheses of Bioactive Compounds

2021 ◽  
Vol 18 ◽  
Author(s):  
Estibaliz Sansinenea ◽  
Aurelio Ortiz
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Bioactive Compounds ◽  
Cascade Reactions ◽  
Biologically Active ◽  
Active Compounds ◽  
Total Syntheses ◽  
Main Structure ◽  
New Methodologies ◽  
High Stereoselectivity

Background: The total syntheses of complex natural products have evolved to include new methodologies to save time, simplifying the form to achieve these natural compounds. Objective: In this review, we have described the asymmetric synthesis of different natural products and biologically active compounds of the last ten years until the current day. Results: An asymmetric organocatalytic reaction is the key to generate stereoselectively the main structure with the required stereochemistry. Conclusion: Even more remarkable, the organocatalytic cascade reactions, which are carried out with high stereoselectivity, as well as a possible approximation of the organocatalysts activation with substrates are also described.

ChemInform Abstract: Chiral-Squaramide-Catalyzed Sulfa-Michael/Aldol Cascade Reactions for Asymmetric Synthesis of Spirothiochromanones.

ChemInform ◽  
2015 ◽  
Vol 46 (50) ◽  
pp. no-no
Author(s):  
Bo-Liang Zhao ◽  
Da-Ming Du
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reactions

An Enzymatic Toolbox for Cascade Reactions: A Showcase for an In Vivo Redox Sequence in Asymmetric Synthesis

ChemCatChem ◽  
2013 ◽  
Vol 5 (12) ◽  
pp. 3524-3528 ◽  
Author(s):  
Nikolin Oberleitner ◽  
Christin Peters ◽  
Jan Muschiol ◽  
Maria Kadow ◽  
Stefan Saß ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reactions

scholarly journals Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael–Henry cascade reactions

2017 ◽  
Vol 13 ◽  
pp. 1342-1349 ◽  
Author(s):  
Yonglei Du ◽  
Jian Li ◽  
Kerong Chen ◽  
Chenglin Wu ◽  
Yu Zhou ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Functional Groups ◽  
Cascade Reactions ◽  
Atom Economy ◽  
Operational Simplicity

The thiourea-catalyzed asymmetric synthesis of highly enantioenriched spirocyclopentaneoxindoles containing chiral amide functional groups using simple 3-substituted oxindoles and nitrovinylacetamide as starting materials was achieved successfully. This protocol features operational simplicity, high atom economy, and high catalytic asymmetry, thus representing a versatile approach to the synthesis of highly enantioenriched spirocyclopentaneoxindoles.

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