Background:
The total syntheses of complex natural products have evolved to include new methodologies to save time, simplifying the form to achieve these natural compounds.
Objective:
In this review, we have described the asymmetric synthesis of different natural products and biologically active compounds of the last ten years until the current day.
Results:
An asymmetric organocatalytic reaction is the key to generate stereoselectively the main structure with the required stereochemistry.
Conclusion:
Even more remarkable, the organocatalytic cascade reactions, which are carried out with high stereoselectivity, as well as a possible approximation of the organocatalysts activation with substrates are also described.
Asymmetric Synthesis of Spirocyclopentane Oxindoles Containing Four Consecutive Stereocenters and Quaternary α-Nitro Esters via Organocatalytic Enantioselective Michael–Michael Cascade Reactions