scholarly journals Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters

2020 ◽  
Author(s):  
Shreyas Bhat ◽  
Daryl A. Guthrie ◽  
Ameya Kasture ◽  
Ali El-Kasaby ◽  
Jianjing Cao ◽  
...  
Keyword(s):  
Dopamine Transporters

scholarly journals Intrinsic motivation in patients with Parkinson’s disease: a neuropsychological investigation of curiosity using dopamine transporter imaging

2021 ◽  
Author(s):  
Yayoi Shigemune ◽  
Iori Kawasaki ◽  
Akira Midorikawa ◽  
Toru Baba ◽  
Atsushi Takeda ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Intrinsic Motivation ◽  
Extrinsic Motivation ◽  
Brain Regions ◽  
Word Recall ◽  
Negative Consequences ◽  
Dopamine Transporters ◽  
Trail Making ◽  
Neuropsychological Investigation

AbstractBoth intrinsic and extrinsic motivation are believed to involve brain regions that are innervated by the dopaminergic pathway. Although dopaminergic neurons in the midbrain deteriorate in Parkinson’s disease (PD), it remains unclear whether intrinsic motivation is impaired in PD patients. To address this issue, we investigated intrinsic motivation in PD patients using a task designed to assess the “Pandora effect,” which constitutes a curiosity for resolving uncertainty, even if this curiosity is likely to result in negative consequences. Twenty-seven PD patients and 27 age-matched healthy controls (HCs) completed a curiosity task in which they were required to decide either to view or skip negative pictures (e.g., snakes, spiders) and an examination battery that included the Mini-Mental State Examination, a verbal fluency test, the Trail Making Test, 10-word recall tests, and questionnaires for behavioral inhibition/activation and depression. DaTSCAN images to assess the distribution of dopamine transporters in the striatum were acquired only from PD patients. The results revealed that PD patients, relative to the HCs, viewed the pictures less frequently under both the certain and uncertain conditions. However, both the PD patients and HCs viewed the pictures at a higher frequency under the uncertain condition than under the certain condition. In the PD patients, the proportion of pictures viewed under the certain condition was positively correlated with the distribution of dopamine transporters in the striatum. These results suggest that despite the overall decreasing level of interest in viewing negative pictures, the motivation to resolve uncertainty is relatively intact in PD patients.

Species Differences in Dopamine Transporters: Postmortem Changes and Glycosylation Differences

2006 ◽  
Vol 61 (2) ◽  
pp. 496-500 ◽  
Author(s):  
Amrat Patel ◽  
George Uhl ◽  
Michael J. Kuhar
Keyword(s):  
Species Differences ◽  
Postmortem Changes ◽  
Dopamine Transporters

scholarly journals The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

2012 ◽  
Vol 287 (22) ◽  
pp. 18524-18534 ◽  
Author(s):  
Simon Bulling ◽  
Klaus Schicker ◽  
Yuan-Wei Zhang ◽  
Thomas Steinkellner ◽  
Thomas Stockner ◽  
...  
Keyword(s):  
Dopamine Transporters ◽  
Mechanistic Basis

A voxel-based PET study of dopamine transporters in Parkinson's disease: Relevance of age at onset

2008 ◽  
Vol 31 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Andrea Panzacchi ◽  
Rosa Maria Moresco ◽  
Valentina Garibotto ◽  
Angelo Antonini ◽  
Clara Gobbo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Age At Onset ◽  
Dopamine Transporters ◽  
Disease Relevance

Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease

Synapse ◽  
1999 ◽  
Vol 31 (2) ◽  
pp. 134-139 ◽  
Author(s):  
Sylvie Chalon ◽  
Patrick Emond ◽  
Sylvie Bodard ◽  
Marie-Paule Vilar ◽  
Cynthia Thiercelin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Time Course ◽  
D2 Receptors ◽  
Striatal Dopamine ◽  
Dopamine Transporters

scholarly journals Rats classified as low or high cocaine locomotor responders: A unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors

2013 ◽  
Vol 37 (8) ◽  
pp. 1738-1753 ◽  
Author(s):  
Dorothy J. Yamamoto ◽  
Anna M. Nelson ◽  
Bruce H. Mandt ◽  
Gaynor A. Larson ◽  
Jacki M. Rorabaugh ◽  
...  
Keyword(s):  
Cocaine Addiction ◽  
Striatal Dopamine ◽  
Dopamine Transporters ◽  
Unique Model

Binding of Mazindol and Analogs to the Human Serotonin and Dopamine Transporters

2013 ◽  
Vol 85 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Kasper Severinsen ◽  
Heidi Koldsø ◽  
Katrine Almind Vinberg Thorup ◽  
Christina Schjøth-Eskesen ◽  
Pernille Thornild Møller ◽  
...  
Keyword(s):  
Dopamine Transporters
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