Fluorescent Derivatives of Diphenyl [1-(N-Peptidylamino)alkyl]phosphonate Esters: Synthesis and Use in the Inhibition and Cellular Localization of Serine Proteases

1994 ◽  
Vol 5 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Ahmed S. Abuelyaman ◽  
Dorothy Hudig ◽  
Susan L. Woodard ◽  
James C. Powers
Keyword(s):  
Serine Proteases ◽  
Cellular Localization ◽  
Phosphonate Esters ◽  
Derivatives Of ◽  
Fluorescent Derivatives

Synthesis, biological evaluation and cellular localization study of fluorescent derivatives of Jiyuan Oridonin A

2021 ◽  
pp. 114048
Author(s):  
Chen Zhou ◽  
Jun-Yuan Zhang ◽  
Han-Bo Liu ◽  
Xiang-Yu Tian ◽  
Yue Liu ◽  
...  
Keyword(s):  
Cellular Localization ◽  
Biological Evaluation ◽  
Localization Study ◽  
Derivatives Of ◽  
Fluorescent Derivatives

scholarly journals Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells

2011 ◽  
Vol 54 (16) ◽  
pp. 5858-5867 ◽  
Author(s):  
Carmen Abate ◽  
John R. Hornick ◽  
Dirk Spitzer ◽  
William G. Hawkins ◽  
Mauro Niso ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cellular Localization ◽  
Pancreatic Tumor ◽  
Receptor Ligand ◽  
Derivatives Of ◽  
Fluorescent Derivatives

Synthesis and Physicochemical Properties of New Fluorescent Derivatives of Cytosine.

ChemInform ◽  
2006 ◽  
Vol 37 (30) ◽  
Author(s):  
Dorota Prukala
Keyword(s):  
Physicochemical Properties ◽  
Derivatives Of ◽  
Fluorescent Derivatives

Synthesis of Fluorescent Derivatives of the Antibiotic Moenomycin A

2002 ◽  
Vol 2002 (7) ◽  
pp. 1149-1162 ◽  
Author(s):  
Andrij Buchynskyy ◽  
Uwe Kempin ◽  
Stefan Vogel ◽  
Lothar Hennig ◽  
Matthias Findeisen ◽  
...  
Keyword(s):  
Moenomycin A ◽  
Derivatives Of ◽  
Fluorescent Derivatives

Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase

2006 ◽  
Vol 16 (9) ◽  
pp. 2518-2521 ◽  
Author(s):  
José-Luis Giner ◽  
Karen A Kehbein ◽  
James A. Cook ◽  
Michele C. Smith ◽  
Chris J. Vlahos ◽  
...  
Keyword(s):  
Phosphatidylinositol 3 Kinase ◽  
Derivatives Of ◽  
Fluorescent Derivatives ◽  
Phosphatidylinositol 3

Synthesis of fluorescent derivatives of 7-methylguanine through reaction with 2-aryl-substituted malondialdehydes: analysis by HPLC with fluorescence detection

1994 ◽  
Vol 93 (3) ◽  
pp. 235-249 ◽  
Author(s):  
Carlos E. Vaca ◽  
Magnus Conradi ◽  
Maria Sievertzon ◽  
Jan Bergman
Keyword(s):  
Fluorescence Detection ◽  
Derivatives Of ◽  
Fluorescent Derivatives

Fluorescent Derivatives of Sphingomyelin: Synthesis, Use as Substrates for Sphingomyelinase and for Diagnosis of Niemann-Pick Disease in Cultured Cells

1986 ◽  
pp. 803-807 ◽  
Author(s):  
Thierry Levade ◽  
Rachel Klar ◽  
Arie Dagan ◽  
Sara Cherbu ◽  
Shimon Gatt
Keyword(s):  
Cultured Cells ◽  
Niemann Pick Disease ◽  
Niemann Pick ◽  
Derivatives Of ◽  
Fluorescent Derivatives ◽  
Pick Disease

A fluorometric determination of sphingomyelinase by use of fluorescent derivatives of sphingomyelin, and its application to diagnosis of Niemann-Pick disease.

1980 ◽  
Vol 26 (1) ◽  
pp. 93-96 ◽  
Author(s):  
S Gatt ◽  
T Dinur ◽  
Y Barenholz
Keyword(s):  
Fatty Acyl ◽  
Great Sensitivity ◽  
Hair Follicles ◽  
Skin Fibroblasts ◽  
Acyl Residue ◽  
Niemann Pick Disease ◽  
Niemann Pick ◽  
Derivatives Of ◽  
Fluorescent Derivatives ◽  
Pick Disease

Abstract We synthesized fluorescent derivatives of sphingomyelin (N-acyl-sphingosylphosphocholine) and used them as substrates for several sphingomyelinases. The following five fluorescent probes, each attached to the terminal carbon atom of the fatty acyl residue, were introduced into sphingomyelin: dansyl, pyrene, carbazole, 4-chloro-7-nitrobenz-2-oxa-1,3-diazole, and anthroic acid. We compared the rates at which the fluoro- and radiolabeled sphingomyelins were hydrolyzed. They were the same with the following three spingomyelinases: (a) a purified enzyme from Staphylococcus aureus; (b) at Triton X100-treated extract of human brain (assayed at pH 7.4 in the presence of Mg2+; and (c) aqueous extracts of brain lysosomes, skin fibroblasts, and amniotic cells, assayed at pH 5.0. Homogenates of skin fibroblasts of a patient with Niemann-Pick disease had practically no activity when assayed at pH 5, with fluorosphingomyelin as substrate. When fluorosphingomyelin was mixed in various proportions with natural sphingomyelin, enzymes from each of the three sources hydrolyzed the two substrates at equal rates. The fluorosphingomyelins can be used to estimate with great sensitivity the sphingomyelinase activity in extracts of tissues or cells, in tears, and probably in hair follicles, as well as diagnose Niemann-Pick disease, either pre- or post-natally

scholarly journals Tight Binding of Bulky Fluorescent Derivatives of Adenosine to the Low Affinity E2ATP Site Leads to Inhibition of Na+/K+-ATPase

1999 ◽  
Vol 274 (4) ◽  
pp. 1971-1978 ◽  
Author(s):  
Detlef Thoenges ◽  
Evzen Amler ◽  
Thomas Eckert ◽  
Wilhelm Schoner
Keyword(s):  
Tight Binding ◽  
Derivatives Of ◽  
Fluorescent Derivatives
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