scholarly journals Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells

2011 ◽  
Vol 54 (16) ◽  
pp. 5858-5867 ◽  
Author(s):  
Carmen Abate ◽  
John R. Hornick ◽  
Dirk Spitzer ◽  
William G. Hawkins ◽  
Mauro Niso ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cellular Localization ◽  
Pancreatic Tumor ◽  
Receptor Ligand ◽  
Derivatives Of ◽  
Fluorescent Derivatives

Synthesis, biological evaluation and cellular localization study of fluorescent derivatives of Jiyuan Oridonin A

2021 ◽  
pp. 114048
Author(s):  
Chen Zhou ◽  
Jun-Yuan Zhang ◽  
Han-Bo Liu ◽  
Xiang-Yu Tian ◽  
Yue Liu ◽  
...  
Keyword(s):  
Cellular Localization ◽  
Biological Evaluation ◽  
Localization Study ◽  
Derivatives Of ◽  
Fluorescent Derivatives

Fluorescent Derivatives of Diphenyl [1-(N-Peptidylamino)alkyl]phosphonate Esters: Synthesis and Use in the Inhibition and Cellular Localization of Serine Proteases

1994 ◽  
Vol 5 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Ahmed S. Abuelyaman ◽  
Dorothy Hudig ◽  
Susan L. Woodard ◽  
James C. Powers
Keyword(s):  
Serine Proteases ◽  
Cellular Localization ◽  
Phosphonate Esters ◽  
Derivatives Of ◽  
Fluorescent Derivatives

Pancreatic Tumor Cells with Mutant K-ras Suppress ERK Activity by MEK-Dependent Induction of MAP Kinase Phosphatase-2

2001 ◽  
Vol 280 (4) ◽  
pp. 992-997 ◽  
Author(s):  
Michele T. Yip-Schneider ◽  
Amy Lin ◽  
Mark S. Marshall
Keyword(s):  
Map Kinase ◽  
Tumor Cells ◽  
Pancreatic Tumor ◽  
Map Kinase Phosphatase ◽  
Erk Activity

Synthesis and Physicochemical Properties of New Fluorescent Derivatives of Cytosine.

ChemInform ◽  
2006 ◽  
Vol 37 (30) ◽  
Author(s):  
Dorota Prukala
Keyword(s):  
Physicochemical Properties ◽  
Derivatives Of ◽  
Fluorescent Derivatives

scholarly journals Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1

2018 ◽  
Vol 218 (1) ◽  
pp. 317-332 ◽  
Author(s):  
Li Qiang ◽  
Hong Cao ◽  
Jing Chen ◽  
Shaun G. Weller ◽  
Eugene W. Krueger ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Pancreatic Tumor ◽  
Binding Protein ◽  
Critical Role ◽  
Inverse Correlation ◽  
Pancreatic Tumors ◽  
Matrix Remodeling ◽  
Peripheral Tissues

The process by which tumor cells mechanically invade through surrounding stroma into peripheral tissues is an essential component of metastatic dissemination. The directed recruitment of the metalloproteinase MT1-MMP to invadopodia plays a critical role in this invasive process. Here, we provide mechanistic insight into MT1-MMP cytoplasmic tail binding protein 1 (MTCBP-1) with respect to invadopodia formation, matrix remodeling, and invasion by pancreatic tumor cells. MTCBP-1 localizes to invadopodia and interacts with MT1-MMP. We find that this interaction displaces MT1-MMP from invadopodia, thereby attenuating their number and function and reducing the capacity of tumor cells to degrade matrix. Further, we observe an inverse correlation between MTCBP-1 and MT1-MMP expression both in cultured cell lines and human pancreatic tumors. Consistently, MTCBP-1–expressing cells show decreased ability to invade in vitro and metastasize in vivo. These findings implicate MTCBP-1 as an inhibitor of the metastatic process.

Synthesis of Fluorescent Derivatives of the Antibiotic Moenomycin A

2002 ◽  
Vol 2002 (7) ◽  
pp. 1149-1162 ◽  
Author(s):  
Andrij Buchynskyy ◽  
Uwe Kempin ◽  
Stefan Vogel ◽  
Lothar Hennig ◽  
Matthias Findeisen ◽  
...  
Keyword(s):  
Moenomycin A ◽  
Derivatives Of ◽  
Fluorescent Derivatives

scholarly journals Evidence that Farnesoid X Receptor ligand through SF‐1 responsive element inhibits aromatase expression in Leydig tumor cells.

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Sebastiano Andò ◽  
Rocco Malivindi ◽  
Pietro Rizza ◽  
Guowei Gu ◽  
Salvatore Panza ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Farnesoid X Receptor ◽  
Receptor Ligand ◽  
Aromatase Expression ◽  
Leydig Tumor Cells ◽  
Responsive Element

Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase

2006 ◽  
Vol 16 (9) ◽  
pp. 2518-2521 ◽  
Author(s):  
José-Luis Giner ◽  
Karen A Kehbein ◽  
James A. Cook ◽  
Michele C. Smith ◽  
Chris J. Vlahos ◽  
...  
Keyword(s):  
Phosphatidylinositol 3 Kinase ◽  
Derivatives Of ◽  
Fluorescent Derivatives ◽  
Phosphatidylinositol 3

Synthesis of fluorescent derivatives of 7-methylguanine through reaction with 2-aryl-substituted malondialdehydes: analysis by HPLC with fluorescence detection

1994 ◽  
Vol 93 (3) ◽  
pp. 235-249 ◽  
Author(s):  
Carlos E. Vaca ◽  
Magnus Conradi ◽  
Maria Sievertzon ◽  
Jan Bergman
Keyword(s):  
Fluorescence Detection ◽  
Derivatives Of ◽  
Fluorescent Derivatives
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