Complete Structural Elucidation of an Oxidized Polysialic Acid Drug Intermediate by Nuclear Magnetic Resonance Spectroscopy

2014 ◽  
Vol 25 (4) ◽  
pp. 665-676 ◽  
Author(s):  
G. Joseph Ray ◽  
Neil Ravenscroft ◽  
Jürgen Siekmann ◽  
Zhenqing Zhang ◽  
Paul Sanders ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Polysialic Acid ◽  
Structural Elucidation ◽  
Resonance Spectroscopy ◽  
Nuclear Magnetic

Correction to Complete Structural Elucidation of an Oxidized Polysialic Acid Drug Intermediate by Nuclear Magnetic Resonance Spectroscopy

2016 ◽  
Vol 27 (8) ◽  
pp. 1958-1958
Author(s):  
G. Joseph Ray ◽  
Neil Ravenscroft ◽  
Jürgen Siekmann ◽  
Zhenqing Zhang ◽  
Paul Sanders ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Polysialic Acid ◽  
Structural Elucidation ◽  
Resonance Spectroscopy ◽  
Nuclear Magnetic

Reaction of Oxidized Polysialic Acid and a Diaminooxy Linker: Characterization and Process Optimization Using Nuclear Magnetic Resonance Spectroscopy

2016 ◽  
Vol 27 (9) ◽  
pp. 2071-2080 ◽  
Author(s):  
G. Joseph Ray ◽  
Jürgen Siekmann ◽  
Richard Scheinecker ◽  
Zhenqing Zhang ◽  
Mikhail V. Gerasimov ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Process Optimization ◽  
Polysialic Acid ◽  
Resonance Spectroscopy ◽  
Nuclear Magnetic

1,2,4-Triazines. IV. The Structural Elucidation of Some New N-Methyl 3-Amino-1,2,4-Triazin-5(2H)-ones by Carbon-13 Nuclear Magnetic Resonance Spectroscopy

1988 ◽  
Vol 41 (4) ◽  
pp. 609 ◽  
Author(s):  
NW Jacobsen ◽  
SE Rose
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Long Range ◽  
Structural Elucidation ◽  
Resonance Spectroscopy ◽  
Amino Group ◽  
Nuclear Magnetic

Methylation of 3-amino-1,2,4-triazin-5(2H)-one yields a mixture of the zwitterion 3-amino-1-methyl-1,2,4-triazinium-5-olate and 3-amino-2- methyl-1,2,4-triazin-5(2H)-one. With appropriate substituents located at position C6 and on the exocyclic amino group at C3, methylation was directed to the N1 or N2 positions exclusively. All methylation isomers were identified by carbon-13 nuclear magnetic resonance spectroscopy by reference to long-range coupling patterns.

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