Mechanism of Inhibition of Human Leukocyte Elastase by .beta.-Lactams. 3. Use of Electrospray Ionization Mass Spectrometry and Two-Dimensional NMR Techniques To Identify .beta.-Lactam-Derived E-I Complexes

Biochemistry ◽  
1995 ◽  
Vol 34 (44) ◽  
pp. 14344-14355 ◽  
Author(s):  
D. J. Underwood ◽  
B. G. Green ◽  
R. Chabin ◽  
S. Mills ◽  
J. B. Doherty ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Human Leukocyte ◽  
Ionization Mass ◽  
Two Dimensional ◽  
Beta Lactam ◽  
Beta Lactams ◽  
Leukocyte Elastase ◽  
Mechanism Of Inhibition ◽  
Human Leukocyte Elastase ◽  
Nmr Techniques

Mechanism of Inhibition of Human Leukocyte Elastase by .beta.-Lactams. 2. Stability, Reactivation Kinetics, and Products of .beta.-Lactam-Derived E-I Complexes

Biochemistry ◽  
1995 ◽  
Vol 34 (44) ◽  
pp. 14331-14343 ◽  
Author(s):  
B. G. Green ◽  
R. Chabin ◽  
S. Mills ◽  
D. J. Underwood ◽  
S. K. Shah ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Beta Lactams ◽  
Leukocyte Elastase ◽  
Mechanism Of Inhibition ◽  
Human Leukocyte Elastase

Electrospray ionization mass spectrometry as a mechanistic tool: Mass of human leukocyte elastase and a .beta.-lactam-derived E-I complex

Biochemistry ◽  
1993 ◽  
Vol 32 (8) ◽  
pp. 2031-2035 ◽  
Author(s):  
W. B. Knight ◽  
K. M. Swiderek ◽  
T. Sakuma ◽  
J. Calaycay ◽  
J. E. Shively ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Human Leukocyte ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Mechanism of inhibition of human leukocyte elastase by monocyclic .beta.-lactams

Biochemistry ◽  
1993 ◽  
Vol 32 (34) ◽  
pp. 8970-8980 ◽  
Author(s):  
R. Chabin ◽  
B. G. Green ◽  
P. Gale ◽  
A. L. Maycock ◽  
H. Weston ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactams ◽  
Leukocyte Elastase ◽  
Mechanism Of Inhibition ◽  
Human Leukocyte Elastase

Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives

Biochemistry ◽  
1992 ◽  
Vol 31 (21) ◽  
pp. 4980-4986 ◽  
Author(s):  
W. B. Knight ◽  
A. L. Maycock ◽  
B. G. Green ◽  
B. M. Ashe ◽  
P. Gale ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Mechanism Of Inhibition ◽  
Human Leukocyte Elastase

Specificity, stability, and potency of monocyclic .beta.-lactam inhibitors of human leukocyte elastase

Biochemistry ◽  
1992 ◽  
Vol 31 (35) ◽  
pp. 8160-8170 ◽  
Author(s):  
W. B. Knight ◽  
B. G. Green ◽  
R. M. Chabin ◽  
P. Gale ◽  
A. L. Maycock ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution

1993 ◽  
Vol 36 (6) ◽  
pp. 771-777 ◽  
Author(s):  
William K. Hagmann ◽  
Amy L. Kissinger ◽  
Shrenik K. Shah ◽  
Paul E. Finke ◽  
Conrad P. Dorn ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase ◽  
Orally Active

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

1992 ◽  
Vol 35 (21) ◽  
pp. 3745-3754 ◽  
Author(s):  
Shrenik K. Shah ◽  
Conrad P. Dorn ◽  
Paul E. Finke ◽  
Jeffrey J. Hale ◽  
William K. Hagmann ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Elastase 1 ◽  
Human Leukocyte Elastase ◽  
Orally Active

Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

1995 ◽  
Vol 38 (13) ◽  
pp. 2449-2462 ◽  
Author(s):  
Paul E. Finke ◽  
Shrenik K. Shah ◽  
Daniel S. Fletcher ◽  
Bonnie M. Ashe ◽  
Karen A. Brause ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Stereospecific Synthesis ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Human Leukocyte Elastase ◽  
Orally Active

The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound

1990 ◽  
Vol 39 (5) ◽  
pp. 919-924 ◽  
Author(s):  
Antonio Baici ◽  
Renzo Pelloso ◽  
Dorothy Hörler
Keyword(s):  
Human Leukocyte ◽  
Kinetic Mechanism ◽  
Leukocyte Elastase ◽  
Mechanism Of Inhibition ◽  
Human Leukocyte Elastase

Structure elucidation and antimicrobial activities of five compounds from Artemisia integrifolia L

2019 ◽  
Vol 74 (9-10) ◽  
pp. 275-278
Author(s):  
Qing-Hu Wang ◽  
Yan-Hua Xu ◽  
Wen-Qiang Bao ◽  
Bi-Le-Ge-Tu Pa ◽  
Jun-Sheng Hao
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Structure Elucidation ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Ionization Mass ◽  
Spectroscopic Methods ◽  
Two Dimensional ◽  
One Dimensional ◽  
Nmr Techniques

Abstract A new compound, integracid (1), together with four known compounds were isolated from the dichloromethane (CH2Cl2) extract from Artemisia integrifolia L. The structures of compounds (1–5) were elucidated by spectroscopic methods, including ultraviolet, infrared (IR), high resolution-electrospray ionization-mass spectrometry (HR-ESI-MS) and extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) techniques, and by comparison with data reported in the references. Antibacterial activities of the compounds were evaluated against various bacteria.

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