Differences in the interaction of the polyene antibiotic amphotericin B with cholesterol- or ergosterol-containing phospholipid vesicles. A circular dichroism and permeability study

Biochemistry ◽  
1983 ◽  
Vol 22 (12) ◽  
pp. 2939-2944 ◽  
Author(s):  
Aline Vertut-Croquin ◽  
Jacques Bolard ◽  
Marie Chabbert ◽  
Claude Gary-Bobo
Keyword(s):  
Circular Dichroism ◽  
Amphotericin B ◽  
Phospholipid Vesicles ◽  
Polyene Antibiotic ◽  
Permeability Study ◽  
Circular Dichroïsm

On the existence of an amphotericin B – sterol complex in lipid vesicles and in propanol–water systems

1987 ◽  
Vol 65 (3) ◽  
pp. 234-238 ◽  
Author(s):  
Ilona Gruda ◽  
Jacques Bolard
Keyword(s):  
Circular Dichroism ◽  
Amphotericin B ◽  
Lipid Bilayer ◽  
Binary Mixtures ◽  
Lipid Vesicles ◽  
Water Systems ◽  
Phospholipid Vesicles ◽  
Positive Cooperativity ◽  
Circular Dichroïsm

The amphotericin B (AmB) – ergosterol complex, formed by interaction of the antibiotic with ergosterol-containing phospholipid vesicles, is associated with the lipid bilayer. It has been shown by circular dichroism studies that the AmB–ergosterol complex formed in water–propanol binary mixtures has a similar structure to that observed in phospholipid vesicles. A positive cooperativity is found for the interaction of AmB with ergosterol. The similar AmB–cholesterol complex is much less stable and rearranges rapidly to a different conformation.

scholarly journals Effect of imidazolium room-temperature ionic liquids on aggregation of amphotericin B: a circular dichroism study

RSC Advances ◽  
2015 ◽  
Vol 5 (98) ◽  
pp. 80325-80329 ◽  
Author(s):  
Laramie P. Jameson ◽  
Sergei V. Dzyuba
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Circular Dichroism ◽  
Amphotericin B ◽  
Room Temperature ◽  
Room Temperature Ionic Liquid ◽  
Room Temperature Ionic Liquids ◽  
Circular Dichroïsm

The aggregate–monomer equilibrium of amphotericin B could be controlled by the structure of the room-temperature ionic liquid.

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