Crystal Structure of Rat Apo-Heme Oxygenase-1 (HO-1):  Mechanism of Heme Binding in HO-1 Inferred from Structural Comparison of the Apo and Heme Complex Forms†,‡

Biochemistry ◽  
2002 ◽  
Vol 41 (23) ◽  
pp. 7293-7300 ◽  
Author(s):  
Masakazu Sugishima ◽  
Hiroshi Sakamoto ◽  
Yoshimitsu Kakuta ◽  
Yoshiaki Omata ◽  
Shunsuke Hayashi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Heme Binding ◽  
Structural Comparison ◽  
Complex Forms

scholarly journals The Arabidopsis locus AT3G03890 encodes a dimeric β-barrel protein implicated in heme degradation

2020 ◽  
Vol 477 (24) ◽  
pp. 4785-4796
Author(s):  
Jia Wang ◽  
Qi Guo ◽  
Xiaoyi Li ◽  
Xiao Wang ◽  
Lin Liu
Keyword(s):  
Crystal Structure ◽  
Recombinant Protein ◽  
Water Molecule ◽  
Heme Oxygenase ◽  
Protein Complex ◽  
Biosynthetic Pathway ◽  
Initial Step ◽  
Heme Iron ◽  
Heme Binding ◽  
New Protein

Plant tetrapyrroles, including heme and bilins, are synthesized in plastids. Heme oxygenase (HO) catalyzes the oxidative cleavage of heme to the linear tetrapyrrole biliverdin as the initial step in bilin biosynthesis. Besides the canonical α-helical HO that is conserved from prokaryotes to human, a subfamily of non-canonical dimeric β-barrel HO has been found in bacteria. In this work, we discovered that the Arabidopsis locus AT3G03890 encodes a dimeric β-barrel protein that is structurally related to the putative non-canonical HO and is located in chloroplasts. The recombinant protein was able to bind and degrade heme in a manner different from known HO proteins. Crystal structure of the heme–protein complex reveals that the heme-binding site is in the interdimer interface and the heme iron is co-ordinated by a fixed water molecule. Our results identify a new protein that may function additionally in the tetrapyrrole biosynthetic pathway.

Expression of the mRNA of Heme-Binding Protein 23 Is Coordinated with That of Heme Oxygenase-1 by Heme and Heavy Metals in Primary Rat Hepatocytes and Hepatoma Cells

Biochemistry ◽  
1995 ◽  
Vol 34 (41) ◽  
pp. 13407-13411 ◽  
Author(s):  
Stephan Immenschuh ◽  
Shin-ichiro Iwahara ◽  
Hiroyuki Satoh ◽  
Christina Nell ◽  
Norbert Katz ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Heme Oxygenase ◽  
Binding Protein ◽  
Rat Hepatocytes ◽  
Hepatoma Cells ◽  
Heme Oxygenase 1 ◽  
Heme Binding ◽  
Primary Rat Hepatocytes ◽  
Heme Binding Protein

scholarly journals Crystal structure of rat heme oxygenase-1 in complex with heme

FEBS Letters ◽  
2000 ◽  
Vol 471 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Masakazu Sugishima ◽  
Yoshiaki Omata ◽  
Yoshimitsu Kakuta ◽  
Hiroshi Sakamoto ◽  
Masato Noguchi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

Crystal Structure of Human Heme Oxygenase-1 in a Complex with Biliverdin†

Biochemistry ◽  
2004 ◽  
Vol 43 (13) ◽  
pp. 3793-3801 ◽  
Author(s):  
Latesh Lad ◽  
Jonathan Friedman ◽  
Huying Li ◽  
B. Bhaskar ◽  
Paul R. Ortiz de Montellano ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

scholarly journals Crystal Structure of Rat Heme Oxygenase-1 in Complex with Biliverdin-Iron Chelate

2003 ◽  
Vol 278 (34) ◽  
pp. 32352-32358 ◽  
Author(s):  
Masakazu Sugishima ◽  
Hiroshi Sakamoto ◽  
Yuichiro Higashimoto ◽  
Masato Noguchi ◽  
Keiichi Fukuyama
Keyword(s):  
Crystal Structure ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Iron Chelate

Distal Regulation of Heme Binding of Heme Oxygenase-1 Mediated by Conformational Fluctuations

Biochemistry ◽  
2014 ◽  
Vol 54 (2) ◽  
pp. 340-348 ◽  
Author(s):  
Erisa Harada ◽  
Masakazu Sugishima ◽  
Jiro Harada ◽  
Keiichi Fukuyama ◽  
Kenji Sugase
Keyword(s):  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Heme Binding

Crystal Structure of Heme Oxygenase from the Gram-Negative PathogenNeisseria meningitidisand a Comparison with Mammalian Heme Oxygenase-1†

Biochemistry ◽  
2001 ◽  
Vol 40 (38) ◽  
pp. 11552-11558 ◽  
Author(s):  
David J. Schuller ◽  
Wenming Zhu ◽  
Igor Stojiljkovic ◽  
Angela Wilks ◽  
Thomas L. Poulos
Keyword(s):  
Crystal Structure ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Gram Negative
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