Do Enzymes Change the Nature of Transition States? Mapping the Transition State for General Acid−Base Catalysis of a Serine Protease‡

Biochemistry ◽  
2003 ◽  
Vol 42 (36) ◽  
pp. 10545-10553 ◽  
Author(s):  
Richard R. Bott ◽  
Gina Chan ◽  
Blanca Domingo ◽  
Grant Ganshaw ◽  
Constance Y. Hsia ◽  
...  
Keyword(s):  
Transition State ◽  
Serine Protease ◽  
Transition States ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid

Reversible hydration of pteridine. General acid-base catalysis, solvent deuterium isotope effects, and transition state characterization

1975 ◽  
Vol 97 (19) ◽  
pp. 5540-5546 ◽  
Author(s):  
Y. Pocker ◽  
D. Bjorkquist ◽  
W. Schaffer ◽  
C. Henderson
Keyword(s):  
Transition State ◽  
Isotope Effects ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Deuterium Isotope Effects ◽  
Reversible Hydration

ChemInform Abstract: Simple General Acid-Base Catalysis and Virtual Transition States for Acetylcholinesterase-Catalyzed Hydrolysis of Phenyl Esters

ChemInform ◽  
1987 ◽  
Vol 18 (21) ◽  
Author(s):  
S. A. ACHESON ◽  
D. DEDOPOULOU ◽  
D. M. QUINN
Keyword(s):  
Transition States ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Hydrolysis Of

scholarly journals Crystal Structures of Streptomyces Coelicolor Methylmalonyl-CoA Epimerase with Substrate or Transition State Analog Contradicts a Simple General Acid-Base Catalytic Mechanism

2021 ◽  
Author(s):  
Lee M Stunkard ◽  
Aaron B Benjamin ◽  
James Bower ◽  
Tyler Huth ◽  
Jeremy Lohman
Keyword(s):  
Transition State ◽  
Crystal Structures ◽  
Conformational Changes ◽  
Catalytic Mechanism ◽  
Streptomyces Coelicolor ◽  
Base Catalysis ◽  
Acid Base ◽  
Transition State Analog ◽  
Catalytic Residues ◽  
General Acid

Crystal structures of Streptomyces coelicolor methylmalonyl-CoA epimerase in the holo-form, with substrate or the putative transition state analog, 2-nitroproionyl-CoA. The proposed catalytic mechanism is general acid-base catalysis. The proposed catalytic residues are too far from the substrate or analog, unless conformational changes take place or some other mechanism is used. <br>

Simple general acid-base catalysis and virtual transition states for acetylcholinesterase-catalyzed hydrolysis of phenyl esters

1987 ◽  
Vol 109 (1) ◽  
pp. 239-245 ◽  
Author(s):  
Scott A. Acheson ◽  
Dimitra Dedopoulou ◽  
Daniel M. Quinn
Keyword(s):  
Transition States ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Hydrolysis Of

scholarly journals Crystal Structures of Streptomyces Coelicolor Methylmalonyl-CoA Epimerase with Substrate or Transition State Analog Contradicts a Simple General Acid-Base Catalytic Mechanism

2021 ◽  
Author(s):  
Lee M Stunkard ◽  
Aaron B Benjamin ◽  
James Bower ◽  
Tyler Huth ◽  
Jeremy Lohman
Keyword(s):  
Transition State ◽  
Crystal Structures ◽  
Conformational Changes ◽  
Catalytic Mechanism ◽  
Streptomyces Coelicolor ◽  
Base Catalysis ◽  
Acid Base ◽  
Transition State Analog ◽  
Catalytic Residues ◽  
General Acid

Crystal structures of Streptomyces coelicolor methylmalonyl-CoA epimerase in the holo-form, with substrate or the putative transition state analog, 2-nitroproionyl-CoA. The proposed catalytic mechanism is general acid-base catalysis. The proposed catalytic residues are too far from the substrate or analog, unless conformational changes take place or some other mechanism is used. <br>

General acid base catalysis

1940 ◽  
pp. 204-248 ◽  
Author(s):  
R. P. Bell
Keyword(s):  
Base Catalysis ◽  
Acid Base ◽  
General Acid
Sign in / Sign up

Export Citation Format

Share Document