Crystal Structures of Streptomyces Coelicolor Methylmalonyl-CoA Epimerase with Substrate or Transition State Analog Contradicts a Simple General Acid-Base Catalytic Mechanism
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Crystal structures of Streptomyces coelicolor methylmalonyl-CoA epimerase in the holo-form, with substrate or the putative transition state analog, 2-nitroproionyl-CoA. The proposed catalytic mechanism is general acid-base catalysis. The proposed catalytic residues are too far from the substrate or analog, unless conformational changes take place or some other mechanism is used. <br>
2021 ◽
1973 ◽
Vol 95
(1)
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pp. 113-119
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1975 ◽
Vol 97
(19)
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pp. 5540-5546
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2014 ◽
Vol 70
(a1)
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pp. C1207-C1207
1997 ◽
Vol 29
(9)
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pp. 647-654
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