Hydrolysis of D-glucono-.delta.-lactone. I. General acid-base catalysis, solvent deuterium isotope effects, and transition state characterization

1973 ◽  
Vol 95 (1) ◽  
pp. 113-119 ◽  
Author(s):  
Y. Pocker ◽  
Edmond. Green
Keyword(s):  
Transition State ◽  
Isotope Effects ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Deuterium Isotope Effects ◽  
Hydrolysis Of

Reversible hydration of pteridine. General acid-base catalysis, solvent deuterium isotope effects, and transition state characterization

1975 ◽  
Vol 97 (19) ◽  
pp. 5540-5546 ◽  
Author(s):  
Y. Pocker ◽  
D. Bjorkquist ◽  
W. Schaffer ◽  
C. Henderson
Keyword(s):  
Transition State ◽  
Isotope Effects ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Deuterium Isotope Effects ◽  
Reversible Hydration

Mechanism of hydration and isomerisation of 4-ethylidene-2,6-di-tert-butyl-2,5-cyclohexadien-1-one. Kinetics, acid-base catalysis and solvent deuterium isotope effects

1979 ◽  
Vol 44 (1) ◽  
pp. 110-122 ◽  
Author(s):  
Jiří Velek ◽  
Bohumír Koutek ◽  
Milan Souček
Keyword(s):  
Aqueous Medium ◽  
Rate Equation ◽  
Kinetic Data ◽  
Isotope Effects ◽  
Base Catalysis ◽  
Quinone Methide ◽  
Reaction Products ◽  
Acid Base ◽  
Deuterium Isotope Effects ◽  
Hydroxybenzyl Alcohol

Competitive hydration and isomerisation of the quinone methide I at 25 °C in an aqueous medium in the region of pH 2.4-13.0 was studied spectrophotometrically. The only reaction products in the studied range of pH are 4-hydroxybenzyl alcohol (II) and 4-hydroxystyrene (III). The form of the overall rate equation corresponds to a general acid-base catalysis. The mechanism of both reactions for three markedly separated pH regions is discussed on the basis of kinetic data and solvent deuterium effect.

scholarly journals Solvent Deuterium Isotope Effects on Acid-Base Reactions. Part IV. Lyonium Ion-Catalyzed Hydrolysis of Tertiary Butyl Acetate in Isotopically Different Waters.

1969 ◽  
Vol 23 ◽  
pp. 713-714
Author(s):  
Pentti Salomaa ◽  
Martti Ketola ◽  
Charles Larsen ◽  
Per Halfdan Nielsen ◽  
Alf A. Lindberg ◽  
...  
Keyword(s):  
Butyl Acetate ◽  
Isotope Effects ◽  
Acid Base ◽  
Tertiary Butyl ◽  
Deuterium Isotope Effects ◽  
Hydrolysis Of

ChemInform Abstract: Simple General Acid-Base Catalysis and Virtual Transition States for Acetylcholinesterase-Catalyzed Hydrolysis of Phenyl Esters

ChemInform ◽  
1987 ◽  
Vol 18 (21) ◽  
Author(s):  
S. A. ACHESON ◽  
D. DEDOPOULOU ◽  
D. M. QUINN
Keyword(s):  
Transition States ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Hydrolysis Of

scholarly journals Crystal Structures of Streptomyces Coelicolor Methylmalonyl-CoA Epimerase with Substrate or Transition State Analog Contradicts a Simple General Acid-Base Catalytic Mechanism

2021 ◽  
Author(s):  
Lee M Stunkard ◽  
Aaron B Benjamin ◽  
James Bower ◽  
Tyler Huth ◽  
Jeremy Lohman
Keyword(s):  
Transition State ◽  
Crystal Structures ◽  
Conformational Changes ◽  
Catalytic Mechanism ◽  
Streptomyces Coelicolor ◽  
Base Catalysis ◽  
Acid Base ◽  
Transition State Analog ◽  
Catalytic Residues ◽  
General Acid

Crystal structures of Streptomyces coelicolor methylmalonyl-CoA epimerase in the holo-form, with substrate or the putative transition state analog, 2-nitroproionyl-CoA. The proposed catalytic mechanism is general acid-base catalysis. The proposed catalytic residues are too far from the substrate or analog, unless conformational changes take place or some other mechanism is used. <br>

Simple general acid-base catalysis and virtual transition states for acetylcholinesterase-catalyzed hydrolysis of phenyl esters

1987 ◽  
Vol 109 (1) ◽  
pp. 239-245 ◽  
Author(s):  
Scott A. Acheson ◽  
Dimitra Dedopoulou ◽  
Daniel M. Quinn
Keyword(s):  
Transition States ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Hydrolysis Of

Do Enzymes Change the Nature of Transition States? Mapping the Transition State for General Acid−Base Catalysis of a Serine Protease‡

Biochemistry ◽  
2003 ◽  
Vol 42 (36) ◽  
pp. 10545-10553 ◽  
Author(s):  
Richard R. Bott ◽  
Gina Chan ◽  
Blanca Domingo ◽  
Grant Ganshaw ◽  
Constance Y. Hsia ◽  
...  
Keyword(s):  
Transition State ◽  
Serine Protease ◽  
Transition States ◽  
Base Catalysis ◽  
Acid Base ◽  
General Acid

Mechanism of hydrolysis of a thiazolium ion: General acid-base catalysis of the breakdown of the tetrahedral addition intermediate

1992 ◽  
Vol 20 (4) ◽  
pp. 296-312 ◽  
Author(s):  
Michael W. Washabaugh ◽  
Charles C. Yang ◽  
James T. Stivers ◽  
Kyung-Sang Lee
Keyword(s):  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Mechanism Of Hydrolysis ◽  
Hydrolysis Of
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