Inhibition of γ-Secretase Activity by a Monoclonal Antibody against the Extracellular Hydrophilic Loop of Presenilin 1

Biochemistry ◽  
2012 ◽  
Vol 52 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Shizuka Takagi-Niidome ◽  
Satoko Osawa ◽  
Taisuke Tomita ◽  
Takeshi Iwatsubo
Keyword(s):  
Monoclonal Antibody ◽  
Presenilin 1 ◽  
Secretase Activity ◽  
Hydrophilic Loop

scholarly journals Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production

2015 ◽  
Vol 133 (3) ◽  
pp. 409-421 ◽  
Author(s):  
Alexandre Matz ◽  
Blanka Halamoda-Kenzaoui ◽  
Romain Hamelin ◽  
Sebastien Mosser ◽  
Jean-René Alattia ◽  
...  
Keyword(s):  
Presenilin 1 ◽  
Secretase Activity ◽  
Aβ Production

P4-296 Fatty acids increase presenilin 1 levels and gamma-secretase activity in PSWT-1 cells

2004 ◽  
Vol 25 ◽  
pp. S559
Author(s):  
Neil S. Shachter ◽  
Yanzhu Liu ◽  
Lin Yang ◽  
Karin Conde-Knape ◽  
Dirk Beher ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Presenilin 1 ◽  
Gamma Secretase ◽  
Secretase Activity

scholarly journals The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing

2010 ◽  
Vol 285 (12) ◽  
pp. 8527-8536 ◽  
Author(s):  
Johanna Wanngren ◽  
Jenny Frånberg ◽  
Annelie I. Svensson ◽  
Hanna Laudon ◽  
Fredrik Olsson ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Presenilin 1 ◽  
Amyloid Β Peptide ◽  
Complex Assembly ◽  
Hydrophilic Loop

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Nature ◽  
10.1038/19077 ◽  
1999 ◽  
Vol 398 (6727) ◽  
pp. 513-517 ◽  
Author(s):  
Michael S. Wolfe ◽  
Weiming Xia ◽  
Beth L. Ostaszewski ◽  
Thekla S. Diehl ◽  
W. Taylor Kimberly ◽  
...  
Keyword(s):  
Presenilin 1 ◽  
Secretase Activity

scholarly journals Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

2003 ◽  
Vol 278 (29) ◽  
pp. 26687-26694 ◽  
Author(s):  
Stephen H. Pasternak ◽  
Richard D. Bagshaw ◽  
Marianne Guiral ◽  
Sunqu Zhang ◽  
Cameron A. Ackerley ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Lysosomal Membrane ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Secretase Activity

scholarly journals The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation

2000 ◽  
Vol 275 (5) ◽  
pp. 3173-3178 ◽  
Author(s):  
W. Taylor Kimberly ◽  
Weiming Xia ◽  
Talat Rahmati ◽  
Michael S. Wolfe ◽  
Dennis J. Selkoe
Keyword(s):  
Amyloid Β ◽  
Presenilin 1 ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Secretase Activity

P4-051: The biological effects of R278I-Presenilin-1 familial mutation on γ-secretase activity and amyloid pathology

2009 ◽  
Vol 5 (4S_Part_15) ◽  
pp. P446-P446
Author(s):  
Takashi Saito ◽  
Takahiro Suemoto ◽  
Naomi Mihira ◽  
Yukio Matsuba ◽  
Jiro Takano ◽  
...  
Keyword(s):  
Biological Effects ◽  
Presenilin 1 ◽  
Amyloid Pathology ◽  
Secretase Activity
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