scholarly journals The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation

2000 ◽  
Vol 275 (5) ◽  
pp. 3173-3178 ◽  
Author(s):  
W. Taylor Kimberly ◽  
Weiming Xia ◽  
Talat Rahmati ◽  
Michael S. Wolfe ◽  
Dennis J. Selkoe
Keyword(s):  
Amyloid Β ◽  
Presenilin 1 ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Secretase Activity

scholarly journals Dysregulation of Amyloid-β Protein Precursor, β-Secretase, Presenilin 1 and 2 Genes in the Rat Selectively Vulnerable CA1 Subfield of Hippocampus Following Transient Global Brain Ischemia

2015 ◽  
Vol 47 (4) ◽  
pp. 1047-1056 ◽  
Author(s):  
Janusz Kocki ◽  
Marzena Ułamek-Kozioł ◽  
Anna Bogucka-Kocka ◽  
Sławomir Januszewski ◽  
Mirosław Jabłoński ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Amyloid Β ◽  
Presenilin 1 ◽  
Amyloid Β Protein ◽  
Global Brain Ischemia ◽  
Protein Precursor ◽  
Β Protein ◽  
Global Brain

Presenilin 1 Regulates the Processing of β-Amyloid Precursor Protein C-Terminal Fragments and the Generation of Amyloid β-Protein in Endoplasmic Reticulum and Golgi†

Biochemistry ◽  
1998 ◽  
Vol 37 (47) ◽  
pp. 16465-16471 ◽  
Author(s):  
Weiming Xia ◽  
Jimin Zhang ◽  
Beth L. Ostaszewski ◽  
William Taylor Kimberly ◽  
Peter Seubert ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Amyloid Precursor Protein ◽  
Protein C ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Β Amyloid

Presenilin-1 polymorphism and amyloid β-protein deposition in fatal head injury

Neuroreport ◽  
1996 ◽  
Vol 8 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Elena Zunarelli ◽  
James A.R. Nicoll ◽  
David I. Graham
Keyword(s):  
Head Injury ◽  
Amyloid Β ◽  
Presenilin 1 ◽  
Amyloid Β Protein ◽  
Protein Deposition ◽  
Β Protein

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Biochemistry ◽  
2000 ◽  
Vol 39 (30) ◽  
pp. 8698-8704 ◽  
Author(s):  
Mark S. Shearman ◽  
Dirk Beher ◽  
Earl E. Clarke ◽  
Huw D. Lewis ◽  
Tim Harrison ◽  
...  
Keyword(s):  
Transition State ◽  
Potent Inhibitor ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Aspartyl Protease ◽  
Protein Precursor ◽  
Β Protein ◽  
Secretase Activity

scholarly journals Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 388
Author(s):  
Michael S. Wolfe
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Potential ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Chemical Probes ◽  
Protein Substrates ◽  
Β Protein ◽  
Secretase Activity

The membrane-embedded γ-secretase complex carries out hydrolysis within the lipid bilayer in proteolyzing nearly 150 different membrane protein substrates. Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of aggregation-prone amyloid β-protein (Aβ) is a defining feature of Alzheimer’s disease (AD). Mutations in APP and in presenilin, the catalytic component of γ-secretase, cause familial AD, strong evidence for a pathogenic role of Aβ. Substrate-based chemical probes—synthetic peptides and peptidomimetics—have been critical to unraveling the complexity of γ-secretase, and small drug-like inhibitors and modulators of γ-secretase activity have been essential for exploring the potential of the protease as a therapeutic target for Alzheimer’s disease. Such chemical probes and therapeutic prototypes will be reviewed here, with concluding commentary on the future directions in the study of this biologically important protease complex and the translation of basic findings into therapeutics.

scholarly journals Overexpression of Mutant Amyloid-β Protein Precursor and Presenilin 1 Modulates Enteric Nervous System

2015 ◽  
Vol 44 (4) ◽  
pp. 1263-1278 ◽  
Author(s):  
Kendra L. Puig ◽  
Brianna M. Lutz ◽  
Siri A. Urquhart ◽  
Andrew A. Rebel ◽  
Xudong Zhou ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Amyloid Β ◽  
Presenilin 1 ◽  
Amyloid Β Protein ◽  
Protein Precursor ◽  
Β Protein
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