scholarly journals Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

2003 ◽  
Vol 278 (29) ◽  
pp. 26687-26694 ◽  
Author(s):  
Stephen H. Pasternak ◽  
Richard D. Bagshaw ◽  
Marianne Guiral ◽  
Sunqu Zhang ◽  
Cameron A. Ackerley ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Lysosomal Membrane ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Secretase Activity

scholarly journals Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates

2010 ◽  
Vol 285 (49) ◽  
pp. 38042-38052 ◽  
Author(s):  
Ping Gong ◽  
Kulandaivelu S. Vetrivel ◽  
Phuong D. Nguyen ◽  
Xavier Meckler ◽  
Haipeng Cheng ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Mutation Analysis ◽  
Broad Spectrum ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Terminal Domain ◽  
Secretase Activity

scholarly journals Effects and Mechanism of Huannao Yicong Decoction Extract on the Ethology of Transgenic APP/PS1 Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Meixia Liu ◽  
Yun Wei ◽  
Yang Yang ◽  
Longtao Liu ◽  
Lin Liang ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Genetic Background ◽  
Morphological Structure ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Control Group ◽  
Model Group ◽  
Secretase Activity ◽  
Hippocampal Ca1 ◽  
Nissl Body

To investigate the mechanism of Huannao Yicong Decoction (HYD) extract on improving of learning memory of transgenic amyloid precursor protein (APP)/presenilin 1 (PS1) mice, we randomly divided 60 transgenic APP/PS1 mice of 3 months old into 4 groups: the model group, the Donepezil group, the HYD-L group, and the HYD-H group, with 15 C57BL/6J mice of the same genetic background as the control group. These mice were gavaged for 6 months in a row. The results showed that the latency was significantly shortened and the number of passing through the original platform was increased. HYD extract can increase the amount of neurons and improve the morphological structure of Nissl body obviously. The γ-secretase activity and the expression of phosphorylated APP, Aβ1-40, and Aβ1-42 in hippocampal CA1 were significantly decreased. The expressions of protein and mRNA of PEN-2 and CREB in hippocampal were significantly downregulated. These results demonstrated that HYD extract can improve the memory ability of transgenic APP/PS1 mice, which was related to the protection of neurons and structure of Nissl body, reducing cleavage of APP and production of Aβ and inhibiting the activity of γ-secretase by decreasing CREB activity because of downregulated expression of PEN-2.

scholarly journals The Role of Presenilin-1 in the γ-Secretase Cleavage of the Amyloid Precursor Protein of Alzheimer's Disease

2000 ◽  
Vol 275 (3) ◽  
pp. 1525-1528 ◽  
Author(s):  
Jean-Noël Octave ◽  
Rachid Essalmani ◽  
Bernadette Tasiaux ◽  
Jean Menager ◽  
Christian Czech ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Presenilin 1

scholarly journals P3-385: Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1(BACE1)

2006 ◽  
Vol 2 ◽  
pp. S489-S489
Author(s):  
Akira Kuzuya ◽  
Kengo Uemura ◽  
Ayae Kinoshita ◽  
Shun Shimohama
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Presenilin 1

scholarly journals Notch1 Competes with the Amyloid Precursor Protein for γ-Secretase and Down-regulates Presenilin-1 Gene Expression

2003 ◽  
Vol 278 (48) ◽  
pp. 47370-47375 ◽  
Author(s):  
Alberto Lleó ◽  
Oksana Berezovska ◽  
Pavan Ramdya ◽  
Hiroaki Fukumoto ◽  
Susan Raju ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Presenilin 1
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