scholarly journals Deletion of Presenilin 1 Hydrophilic Loop Sequence Leads to Impaired  -Secretase Activity and Exacerbated Amyloid Pathology

2006 ◽  
Vol 26 (14) ◽  
pp. 3845-3854 ◽  
Author(s):  
Y. Deng
Keyword(s):  
Presenilin 1 ◽  
Amyloid Pathology ◽  
Secretase Activity ◽  
Loop Sequence ◽  
Hydrophilic Loop

P4-051: The biological effects of R278I-Presenilin-1 familial mutation on γ-secretase activity and amyloid pathology

2009 ◽  
Vol 5 (4S_Part_15) ◽  
pp. P446-P446
Author(s):  
Takashi Saito ◽  
Takahiro Suemoto ◽  
Naomi Mihira ◽  
Yukio Matsuba ◽  
Jiro Takano ◽  
...  
Keyword(s):  
Biological Effects ◽  
Presenilin 1 ◽  
Amyloid Pathology ◽  
Secretase Activity

Inhibition of γ-Secretase Activity by a Monoclonal Antibody against the Extracellular Hydrophilic Loop of Presenilin 1

Biochemistry ◽  
2012 ◽  
Vol 52 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Shizuka Takagi-Niidome ◽  
Satoko Osawa ◽  
Taisuke Tomita ◽  
Takeshi Iwatsubo
Keyword(s):  
Monoclonal Antibody ◽  
Presenilin 1 ◽  
Secretase Activity ◽  
Hydrophilic Loop

scholarly journals Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production

2015 ◽  
Vol 133 (3) ◽  
pp. 409-421 ◽  
Author(s):  
Alexandre Matz ◽  
Blanka Halamoda-Kenzaoui ◽  
Romain Hamelin ◽  
Sebastien Mosser ◽  
Jean-René Alattia ◽  
...  
Keyword(s):  
Presenilin 1 ◽  
Secretase Activity ◽  
Aβ Production

Coenzyme Q10 Attenuates β-Amyloid Pathology in the Aged Transgenic Mice with Alzheimer Presenilin 1 Mutation

2008 ◽  
Vol 34 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Xifei Yang ◽  
Ying Yang ◽  
Geng Li ◽  
Jianzhi Wang ◽  
Edward S Yang
Keyword(s):  
Transgenic Mice ◽  
Coenzyme Q10 ◽  
Presenilin 1 ◽  
Amyloid Pathology ◽  
Presenilin 1 Mutation ◽  
Β Amyloid

P4-296 Fatty acids increase presenilin 1 levels and gamma-secretase activity in PSWT-1 cells

2004 ◽  
Vol 25 ◽  
pp. S559
Author(s):  
Neil S. Shachter ◽  
Yanzhu Liu ◽  
Lin Yang ◽  
Karin Conde-Knape ◽  
Dirk Beher ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Presenilin 1 ◽  
Gamma Secretase ◽  
Secretase Activity

scholarly journals The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing

2010 ◽  
Vol 285 (12) ◽  
pp. 8527-8536 ◽  
Author(s):  
Johanna Wanngren ◽  
Jenny Frånberg ◽  
Annelie I. Svensson ◽  
Hanna Laudon ◽  
Fredrik Olsson ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Presenilin 1 ◽  
Amyloid Β Peptide ◽  
Complex Assembly ◽  
Hydrophilic Loop

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Nature ◽  
10.1038/19077 ◽  
1999 ◽  
Vol 398 (6727) ◽  
pp. 513-517 ◽  
Author(s):  
Michael S. Wolfe ◽  
Weiming Xia ◽  
Beth L. Ostaszewski ◽  
Thekla S. Diehl ◽  
W. Taylor Kimberly ◽  
...  
Keyword(s):  
Presenilin 1 ◽  
Secretase Activity
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