Faculty Opinions recommendation of Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

2003 ◽  
Author(s):  
Raphael Kopan
Keyword(s):  
Presenilin 1 ◽  
Gamma Secretase ◽  
Secretase Activity

P4-296 Fatty acids increase presenilin 1 levels and gamma-secretase activity in PSWT-1 cells

2004 ◽  
Vol 25 ◽  
pp. S559
Author(s):  
Neil S. Shachter ◽  
Yanzhu Liu ◽  
Lin Yang ◽  
Karin Conde-Knape ◽  
Dirk Beher ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Presenilin 1 ◽  
Gamma Secretase ◽  
Secretase Activity

scholarly journals Presenilin 1 is linked with gamma -secretase activity in the detergent solubilized state

2000 ◽  
Vol 97 (11) ◽  
pp. 6138-6143 ◽  
Author(s):  
Y.-M. Li ◽  
M.-T. Lai ◽  
M. Xu ◽  
Q. Huang ◽  
J. DiMuzio-Mower ◽  
...  
Keyword(s):  
Presenilin 1 ◽  
Gamma Secretase ◽  
Secretase Activity

scholarly journals Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production

2015 ◽  
Vol 133 (3) ◽  
pp. 409-421 ◽  
Author(s):  
Alexandre Matz ◽  
Blanka Halamoda-Kenzaoui ◽  
Romain Hamelin ◽  
Sebastien Mosser ◽  
Jean-René Alattia ◽  
...  
Keyword(s):  
Presenilin 1 ◽  
Secretase Activity ◽  
Aβ Production

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Nature ◽  
10.1038/19077 ◽  
1999 ◽  
Vol 398 (6727) ◽  
pp. 513-517 ◽  
Author(s):  
Michael S. Wolfe ◽  
Weiming Xia ◽  
Beth L. Ostaszewski ◽  
Thekla S. Diehl ◽  
W. Taylor Kimberly ◽  
...  
Keyword(s):  
Presenilin 1 ◽  
Secretase Activity

scholarly journals Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

2003 ◽  
Vol 278 (29) ◽  
pp. 26687-26694 ◽  
Author(s):  
Stephen H. Pasternak ◽  
Richard D. Bagshaw ◽  
Marianne Guiral ◽  
Sunqu Zhang ◽  
Cameron A. Ackerley ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Lysosomal Membrane ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Secretase Activity
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