Comparison of the Structural Properties of the Active Site Cavities of Human and Rat Monoamine Oxidase A and B in Their Soluble and Membrane-Bound Forms†

Biochemistry ◽  
2008 ◽  
Vol 47 (2) ◽  
pp. 526-536 ◽  
Author(s):  
Anup K. Upadhyay ◽  
Jin Wang ◽  
Dale E. Edmondson
Keyword(s):  
Monoamine Oxidase ◽  
Structural Properties ◽  
Active Site ◽  
Monoamine Oxidase A ◽  
Membrane Bound

Interactions of D-amphetamine with the active site of monoamine oxidase-A

2003 ◽  
Vol 11 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Rona R. Ramsay ◽  
Dominic J. B. Hunter
Keyword(s):  
Monoamine Oxidase ◽  
Active Site ◽  
Monoamine Oxidase A

scholarly journals Pirlindole analogs as probes of the active site of Monoamine Oxidase A

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Rona Ruth Ramsay ◽  
Gu Liu ◽  
Nicholas J Westwood
Keyword(s):  
Monoamine Oxidase ◽  
Active Site ◽  
Monoamine Oxidase A

Computer visualisation of the active site of monoamine oxidase-A by means of selective inhibitors

2003 ◽  
Vol 11 (2) ◽  
pp. 135-143
Author(s):  
Alexei E. Medvedev ◽  
Alexis S. Ivanov ◽  
Alexander V. Veselovsky
Keyword(s):  
Monoamine Oxidase ◽  
Active Site ◽  
Monoamine Oxidase A ◽  
Selective Inhibitors

scholarly journals Insights into enzyme point mutation effect by molecular simulation: phenylethylamine oxidation catalyzed by monoamine oxidase A

2016 ◽  
Vol 18 (19) ◽  
pp. 13346-13356 ◽  
Author(s):  
Gabriel Oanca ◽  
Miha Purg ◽  
Janez Mavri ◽  
Jean C. Shih ◽  
Jernej Stare
Keyword(s):  
Monoamine Oxidase ◽  
Point Mutation ◽  
Molecular Simulation ◽  
Active Site ◽  
Monoamine Oxidase A ◽  
Substrate Molecule

The active site of monoamine oxidase A with a phenylethylamine substrate molecule and residue 335 subjected to mutation.

scholarly journals Interactions of imidazoline ligands with the active site of purified monoamine oxidase A

FEBS Journal ◽  
2007 ◽  
Vol 274 (6) ◽  
pp. 1567-1575 ◽  
Author(s):  
Tadeusz Z. E. Jones ◽  
Laura Giurato ◽  
Salvatore Guccione ◽  
Rona R. Ramsay
Keyword(s):  
Monoamine Oxidase ◽  
Active Site ◽  
Monoamine Oxidase A

Influence of Protonation on Substrate and Inhibitor Interactions at the Active Site of Human Monoamine Oxidase-A

2012 ◽  
Vol 52 (5) ◽  
pp. 1213-1221 ◽  
Author(s):  
Gerald Zapata-Torres ◽  
Angelica Fierro ◽  
Sebastian Miranda-Rojas ◽  
Carlos Guajardo ◽  
Patricio Saez-Briones ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Active Site ◽  
Monoamine Oxidase A

Membrane Attachment Facilitates Ligand Access to the Active Site in Monoamine Oxidase A

Biochemistry ◽  
2009 ◽  
Vol 48 (25) ◽  
pp. 5864-5873 ◽  
Author(s):  
Rossen Apostolov ◽  
Yasushige Yonezawa ◽  
Daron M. Standley ◽  
Gota Kikugawa ◽  
Yu Takano ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Active Site ◽  
Monoamine Oxidase A ◽  
Membrane Attachment

scholarly journals Analysis of Conserved Active Site Residues in Monoamine Oxidase A and B and Their Three-dimensional Molecular Modeling

2002 ◽  
Vol 277 (19) ◽  
pp. 17209-17216 ◽  
Author(s):  
Rani Maurice Geha ◽  
Kevin Chen ◽  
Johan Wouters ◽  
Frédéric Ooms ◽  
Jean Chen Shih
Keyword(s):  
Molecular Modeling ◽  
Monoamine Oxidase ◽  
Active Site ◽  
Three Dimensional ◽  
Monoamine Oxidase A ◽  
Active Site Residues

scholarly journals Rat liver mitochondrial monoamine oxidase. A change in the reaction mechanism on solubilization

1975 ◽  
Vol 145 (2) ◽  
pp. 311-321 ◽  
Author(s):  
M D Houslay ◽  
K F Tipton
Keyword(s):  
Monoamine Oxidase ◽  
Rat Liver ◽  
Bound State ◽  
Monoamine Oxidase A ◽  
Rate Equations ◽  
British Library ◽  
Ping Pong ◽  
Mitochondrial Monoamine Oxidase ◽  
Lending Library ◽  
Membrane Bound

1. The kinetics of benzylamine oxidation by a soluble preparation of rat liver mitochondrial monoamine oxidase were investigated and were shown to conform to adouble-displacement (or Ping Pong) mechanism. 2. The pathway differs in detail from that followed by other amine oxidases, including the membrane-bound enzyme in rat liver mitochondrial outer membranes. 3. It is suggested taht the conformation of the protein in the soluble state differs from that in the membrane-bound state. 4. The full rate equations for this mechanism have been deposited as Supplementary Publication SUP 50039 (5pages) at the British Library (lending Division) (formely the National Lending Library for Science and Technology), Boston Spa, Yorks, LS237BQ, U.K.. from whom copies can be obtained on the terms indicated in Biochem. J (1975) 145,5.

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