Detection of the TCDD Binding-Fingerprint within the Ah Receptor Ligand Binding Domain by Structurally Driven Mutagenesis and Functional Analysis

Alessandro Pandini; Anatoly A. Soshilov; Yujuan Song; Jing Zhao; Laura Bonati; Michael S. Denison

doi:10.1021/bi900259z

Detection of the TCDD Binding-Fingerprint within the Ah Receptor Ligand Binding Domain by Structurally Driven Mutagenesis and Functional Analysis

Biochemistry ◽

10.1021/bi900259z ◽

2009 ◽

Vol 48 (25) ◽

pp. 5972-5983 ◽

Cited By ~ 78

Author(s):

Alessandro Pandini ◽

Anatoly A. Soshilov ◽

Yujuan Song ◽

Jing Zhao ◽

Laura Bonati ◽

...

Keyword(s):

Functional Analysis ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Ah Receptor ◽

Receptor Ligand

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Modeling the binding of diverse ligands within the Ah receptor ligand binding domain

Scientific Reports ◽

10.1038/s41598-019-47138-z ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 20

Author(s):

Sara Giani Tagliabue ◽

Samantha C. Faber ◽

Stefano Motta ◽

Michael S. Denison ◽

Laura Bonati

Keyword(s):

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Ah Receptor ◽

Receptor Ligand

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Comparative Analysis of Homology Models of the Ah Receptor Ligand Binding Domain: Verification of Structure–Function Predictions by Site-Directed Mutagenesis of a Nonfunctional Receptor

Biochemistry ◽

10.1021/bi301457f ◽

2013 ◽

Vol 52 (4) ◽

pp. 714-725 ◽

Cited By ~ 48

Author(s):

Domenico Fraccalvieri ◽

Anatoly A. Soshilov ◽

Sibel I. Karchner ◽

Diana G. Franks ◽

Alessandro Pandini ◽

...

Keyword(s):

Comparative Analysis ◽

Ligand Binding ◽

Structure Function ◽

Binding Domain ◽

Ligand Binding Domain ◽

Site Directed Mutagenesis ◽

Ah Receptor ◽

Directed Mutagenesis ◽

Receptor Ligand ◽

Homology Models

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Three-dimensional structure of homodimeric androgen receptor ligand-binding domain

Endocrine Abstracts ◽

10.1530/endoabs.42.il3 ◽

2016 ◽

Author(s):

Eva Estebanez Perpina

Keyword(s):

Androgen Receptor ◽

Ligand Binding ◽

Three Dimensional ◽

Binding Domain ◽

Ligand Binding Domain ◽

Dimensional Structure ◽

Receptor Ligand ◽

Three Dimensional Structure

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Human formyl peptide receptor ligand binding domain(s). Studies using an improved mutagenesis/expression vector reveal a novel mechanism for the regulation of receptor occupancy.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)31671-x ◽

1994 ◽

Vol 269 (36) ◽

pp. 22485-22487

Author(s):

H.D. Perez ◽

L. Vilander ◽

W.H. Andrews ◽

R. Holmes

Keyword(s):

Ligand Binding ◽

Expression Vector ◽

Receptor Occupancy ◽

Binding Domain ◽

Ligand Binding Domain ◽

Formyl Peptide Receptor ◽

Receptor Ligand ◽

Peptide Receptor ◽

Formyl Peptide

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Mechanism of Vitamin D Receptor Ligand-Binding Domain Regulation Studied by gREST Simulations

Journal of Chemical Information and Modeling ◽

10.1021/acs.jcim.1c00534 ◽

2021 ◽

Author(s):

Toru Ekimoto ◽

Takafumi Kudo ◽

Tsutomu Yamane ◽

Mitsunori Ikeguchi

Keyword(s):

Vitamin D ◽

Ligand Binding ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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Application of Oestrogen Receptor Ligand Binding Domain to the Generic Isolation of Oestrogens by Receptor Affinity Chromatography

Chromatographia ◽

10.1365/s10337-003-0246-4 ◽

2004 ◽

Vol 59 (S1) ◽

pp. S123-S130 ◽

Cited By ~ 1

Author(s):

M. F. Byford ◽

M. J. Sauer

Keyword(s):

Ligand Binding ◽

Affinity Chromatography ◽

Oestrogen Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Receptor Affinity

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Simulations of the Estrogen Receptor Ligand-Binding Domain: Affinity of Natural Ligands and Xenoestrogens

Journal of Medicinal Chemistry ◽

10.1021/jm001045d ◽

2000 ◽

Vol 43 (24) ◽

pp. 4594-4605 ◽

Cited By ~ 72

Author(s):

B. Chris Oostenbrink ◽

Jed W. Pitera ◽

Marola M. H. van Lipzig ◽

John H. N. Meerman ◽

Wilfred F. van Gunsteren

Keyword(s):

Estrogen Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Natural Ligands ◽

Estrogen Receptor Ligand

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Dynamic and Strucutral Effects of Ligand and Coregulator Binding on Estrogen Receptor Ligand Binding Domain Measured by Electron Paramagnetic Resonance

Biophysical Journal ◽

10.1016/j.bpj.2008.12.2966 ◽

2009 ◽

Vol 96 (3) ◽

pp. 548a

Author(s):

Stefano V. Gulla

Keyword(s):

Electron Paramagnetic Resonance ◽

Estrogen Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Paramagnetic Resonance ◽

Receptor Ligand ◽

Estrogen Receptor Ligand ◽

Electron Paramagnetic

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Comparative analysis of interactions between aryl hydrocarbon receptor ligand binding domain with its ligands: a computational study

BMC Structural Biology ◽

10.1186/s12900-018-0095-2 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 6

Author(s):

Kumaraswamy Naidu Chitrala ◽

Xiaoming Yang ◽

Prakash Nagarkatti ◽

Mitzi Nagarkatti

Keyword(s):

Comparative Analysis ◽

Ligand Binding ◽

Aryl Hydrocarbon Receptor ◽

Computational Study ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Aryl Hydrocarbon Receptor Ligand ◽

Aryl Hydrocarbon

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Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.06.054 ◽

2012 ◽

Vol 20 (19) ◽

pp. 5992-6002 ◽

Cited By ~ 11

Author(s):

Atilla Akdemir ◽

Ewald Edink ◽

Andrew J. Thompson ◽

Sarah C.R. Lummis ◽

Albert J. Kooistra ◽

...

Keyword(s):

Crystal Structure ◽

Ligand Binding ◽

In Silico ◽

Nicotinic Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligands ◽

In Silico Screening ◽

Receptor Ligand

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