scholarly journals Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

2011 ◽  
Vol 2 (10) ◽  
pp. 572-577 ◽  
Author(s):  
Haibo Yu ◽  
Meng Wu ◽  
Steven D. Townsend ◽  
Beiyan Zou ◽  
Shunyou Long ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Potassium Channel Opener ◽  
Structure Activity ◽  
Channel Opener ◽  
Relationship Of

Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers

2004 ◽  
Vol 47 (11) ◽  
pp. 2887-2896 ◽  
Author(s):  
Yong-Jin Wu ◽  
Huan He ◽  
Li-Qiang Sun ◽  
Alexandre L'Heureux ◽  
Jie Chen ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Potassium Channel Openers ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

2012 ◽  
Vol 8 ◽  
pp. 841-849 ◽  
Author(s):  
Chao Che ◽  
Song Li ◽  
Bo Yang ◽  
Shengchang Xin ◽  
Zhixiong Yu ◽  
...  
Keyword(s):  
Potent Inhibitor ◽  
Structure Activity Relationship ◽  
Hedgehog Pathway ◽  
Activity Relationship ◽  
Synthesis And Characterization ◽  
Important Class ◽  
Diversity Oriented Synthesis ◽  
Structure Activity ◽  
Relationship Of

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pathway inhibitors.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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