Microbial Fuel Cells (MFC) are the main topic of this chapter. Different types of electrochemical devices are presented and their typical power output is compared with other energy sources, providing a framework for the uses and applications of MFC technology. Following an historical approach of how this technology came to be, a more detailed description of some aspects of a typical microbial fuel cell is then brought forward. The energy harvesting concept, its use on low power wireless systems and maximum power point tracking (MPPT) techniques are presented and described. Wastewater treatment plants are a kind of infrastructure where this technology could be applied with a major success to power wireless sensing networks. An experimental setup, develop to improve the use of MFC in waste water treatment plants is presented. This chapter also provides a review on research trends for microbial fuel cells and maximum power point tracking algorithms, therefore, pointing current researches on this technology.