Temperature Dependence of the Carbon Isotope Effect in the Dehydration of Formic Acid by Concentrated Sulfuric Acid

1962 ◽  
Vol 84 (10) ◽  
pp. 1813-1815 ◽  
Author(s):  
Jacob. Bigeleisen ◽  
Rudy H. Haschemeyer ◽  
Max. Wolfsberg ◽  
Peter E. Yankwich
Keyword(s):  
Sulfuric Acid ◽  
Formic Acid ◽  
Temperature Dependence ◽  
Carbon Isotope ◽  
Isotope Effect ◽  
Carbon Isotope Effect ◽  
Concentrated Sulfuric Acid

TEMPERATURE DEPENDENCE OF THE CARBON ISOTOPE EFFECT IN THE DECARBONYLATION OF LIQUID FORMIC ACID

1963 ◽  
Vol 67 (3) ◽  
pp. 694-696 ◽  
Author(s):  
Peter E. Yankwich ◽  
Rudy H. Haschemeyer
Keyword(s):  
Formic Acid ◽  
Temperature Dependence ◽  
Carbon Isotope ◽  
Isotope Effect ◽  
Carbon Isotope Effect

Carbon isotope effect studies in the mechanism of reactions of alkynes with formic acid

1997 ◽  
Vol 223 (1-2) ◽  
pp. 41-45
Author(s):  
M. Zieliński ◽  
A. Zielińska ◽  
H. Papiernik-Zielińska ◽  
G. Czarnota ◽  
G. Kasprzyk ◽  
...  
Keyword(s):  
Formic Acid ◽  
Carbon Isotope ◽  
Isotope Effect ◽  
Carbon Isotope Effect

Temperature Dependence of the Carbon Isotope Effect in the Acid Hydrolysis of Urea

1958 ◽  
Vol 80 (8) ◽  
pp. 1835-1838 ◽  
Author(s):  
Peter E. Yankwich ◽  
Audrey E. Veazie
Keyword(s):  
Temperature Dependence ◽  
Acid Hydrolysis ◽  
Carbon Isotope ◽  
Isotope Effect ◽  
Carbon Isotope Effect ◽  
Hydrolysis Of ◽  
Hydrolysis Of Urea

Carbon isotope effect studies in the mechanism of reactions of alkynes with formic acid

1996 ◽  
Vol 210 (1) ◽  
pp. 15-25 ◽  
Author(s):  
M. Zieliński ◽  
H. Papiernik-Zielińska ◽  
A. Zielińska ◽  
G. Kasprzyk ◽  
G. Czarnota ◽  
...  
Keyword(s):  
Formic Acid ◽  
Carbon Isotope ◽  
Isotope Effect ◽  
Carbon Isotope Effect

A Headspace Gas Chromatographic Method for Determination of Formic acid Content in Isosulfan Blue and in Various Drugs

2021 ◽  
Vol 37 (2) ◽  
pp. 321-329
Author(s):  
Nilesh Takale ◽  
Neelakandan Kaliyaperumal ◽  
Gopalakrishnan Mannathusamy ◽  
Rajarajan Govindasamy
Keyword(s):  
Sulfuric Acid ◽  
Formic Acid ◽  
Chromatographic Method ◽  
Isopropyl Alcohol ◽  
Class Iii ◽  
Drug Substances ◽  
Headspace Gas ◽  
Concentrated Sulfuric Acid ◽  
Gas Chromatographic Method

The Pharmaceutical industry uses formic acid in the manufacturing of various drug substances or API. At the time of manufacturing of API formic acid is use as an oxidizing agent. Formic acid is the simplest carboxylic acid. It also called methanoic acid.Formic acid present in API at high concentrations is very hazardous but in low concentrations is very beneficial. The developed and validated method was short, precise, cost effective and reproducible with FID detector and easy to use. The method is a selective and superficial analytical method for determination of formic acid in different drug substances. We report here the development and validation study of headspace gas chromatographic method to determine formic acid in different drug substances we are reported here. As per this method, the drug sample was dissolved in 0.1% (v/v) of concentrated sulfuric acid in isopropyl alcohol (IPA) in a GC headspace vial and 0.1% (v/v) of concentrated sulfuric acid in isopropyl alcohol used as a diluent. A AB-Inowax capillary column (30 m x 0.32 mm I.D. and 0.5 µm film thickness) was used under gradient conditions with FID. The formic acid peak was well separated from all other solvents that are used in synthesis of particular drug substance. The LOD and LOQof the method for formic acid are 82 ppm and 249 ppm respectively. Formic acid are low toxic class-III solvent as per ICH guideline.

Atomic Substitution And Carbon Isotope Effect In Superconducting MgCNi3

2006 ◽  
Author(s):  
T. Klimczuk ◽  
V. Gupta ◽  
M. Avdeev ◽  
J. D. Jorgensen ◽  
R. J. Cava
Keyword(s):  
Carbon Isotope ◽  
Isotope Effect ◽  
Carbon Isotope Effect ◽  
Atomic Substitution

Carbon isotope effect on dehydration of bicarbonate ion catalyzed by carbonic anhydrase

Biochemistry ◽  
1985 ◽  
Vol 24 (19) ◽  
pp. 5143-5147 ◽  
Author(s):  
Piotr Paneth ◽  
Marion H. O'Leary
Keyword(s):  
Carbonic Anhydrase ◽  
Carbon Isotope ◽  
Isotope Effect ◽  
Carbon Isotope Effect

Equilibrium carbon isotope effect on a decarboxylation reaction

1978 ◽  
Vol 80 (1) ◽  
pp. 155-160 ◽  
Author(s):  
Marion H. O'Leary ◽  
Crayton J. Yapp
Keyword(s):  
Carbon Isotope ◽  
Isotope Effect ◽  
Decarboxylation Reaction ◽  
Carbon Isotope Effect

A Carbon Isotope Effect in the Decarboxylation of the Anisoyloxy Radical

Nature ◽  
1963 ◽  
Vol 197 (4874) ◽  
pp. 1294-1295
Author(s):  
T. H. BATES ◽  
J. C. BEVINGTON
Keyword(s):  
Carbon Isotope ◽  
Isotope Effect ◽  
Carbon Isotope Effect
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