Optimization of the Relaxivity of MRI Contrast Agents:  Effect of Poly(ethylene glycol) Chains on the Water-Exchange Rates of GdIIIComplexes

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A structural analysis of Ln(iii)-DOTA-like complexes helps to elucidate observed trends in the water exchange rate of Gd(iii)-based MRI contrast agents.


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PEGylated Mn2+ complexes show higher relaxivity and longer blood circulation time than free Mn2+ complexes.


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