The Behavior of Pyrogallol Trimethyl Ether and 3,4,5-Trimethoxybenzonitrile toward Grignard Reagents

1942 ◽  
Vol 64 (9) ◽  
pp. 2085-2086 ◽  
Author(s):  
Charles D. Hurd ◽  
H. E. Winberg
Keyword(s):  
Grignard Reagents ◽  
Trimethyl Ether

Colouring matters of Australian plants. XXIV. Haemofluorone B : New synthetic models and a revised structure

1981 ◽  
Vol 34 (3) ◽  
pp. 587 ◽  
Author(s):  
AL Chaffee ◽  
RG Cooke ◽  
IJ Dagley ◽  
P Perlmutter ◽  
RL Thomas
Keyword(s):  
Grignard Reagents ◽  
Trimethyl Ether ◽  
Synthetic Models

The occurrence of haemofluorone B in Anigozanthos rufus and Conostylis setosa has been confirmed. The revised structure 5,8,9-trihydroxy-3H-naphtho[2,1,8-mna]xanthen-3-one is now proposed for this pigment. Dihydroxyanigorufone has also been found in Conostylis setosa and the structure 9-(3,4-dihydroxyphenyl)-2-hydroxy-lH-phenalen-l-one has been confirmed by synthesis of the trimethyl ether. Some model arylphenalenones and naphthoxanthenones have been prepared fromnaphthylphenylpropanones and some unusual products have been obtained by photolysis of arylphenalenonesand by the reactions of Grignard reagents with phenalenones.

Copper (I) Catalysed Conjugate Addition of Grignard Reagents to Enones

10.1039/sp35 ◽  
2001 ◽  
Author(s):  
Kevin Booker-Milburn
Keyword(s):  
Conjugate Addition ◽  
Grignard Reagents

Asymmetric 1,2- and 1,3-Inductions and Solvent Dependence Found in Chelate-Controlled Additions of Grignard Reagents and Cuprates to Chiral β-Formyl Esters. Stereoselective Synthesis of γ-Lactones

Synlett ◽  
1989 ◽  
Vol 1989 (01) ◽  
pp. 24-25 ◽  
Author(s):  
Agnes Janowitz ◽  
Thomas Kunz ◽  
Gabriele Handke ◽  
Hans-Ulrich Reissig
Keyword(s):  
Stereoselective Synthesis ◽  
Grignard Reagents ◽  
Solvent Dependence

Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents

2020 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Cassandra R. Youshaw ◽  
Mingbin Yuan ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Turnover Frequency ◽  
Diverse Range ◽  
Cascade Cyclization ◽  
Radical Cascade

The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleophiles, alkyl halides, and unactivated olefins bearing diverse functional groups to yield the desired 1,2-alkylarylated products with high regiocontrol. Further, we demonstrate that this protocol is amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines via a three-component radical cascade cyclization/arylation that forges three new C-C bonds.

Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes

2019 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Mingbin Yuan ◽  
Chris Acha ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Mechanistic Studies ◽  
Radical Intermediates ◽  
Design And Implementation ◽  
Solvent Cage ◽  
Radical Cascade ◽  
Radical Processes

Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven approach. Mechanistic studies support the diffusion of the alkyl radical intermediates out of the solvent cage to participate in an intra- or -intermolecular radical cascade with the VCP followed by re-entering the Fe radical cross-coupling cycle to undergo selective C(sp2)-C(sp3) bond formation. Overall, we provide new design principles for Fe-mediated radical processes and underscore the potential of using combined computations and experiments to accelerate the development of challenging transformations.

Alkyl 1-[2-(oxido anion)-, 3-, 4-, 5-alkyl substituted]phenyl ketyl radicals

1979 ◽  
Vol 44 (6) ◽  
pp. 1731-1741 ◽  
Author(s):  
Andrej Staško ◽  
Ľubomír Malík ◽  
Alexander Tkáč ◽  
Vladimír Adamčík ◽  
Eva Maťašová
Keyword(s):  
Electron Donor ◽  
Unpaired Electron ◽  
Grignard Reagents ◽  
Slight Effect ◽  
Benzene Nucleus ◽  
Alkyl Groups ◽  
Splitting Constant

Reactions of R2,R3-alkyl substituted 2-hydroxybenzenecarboxylic acids 2-HO-C6H2R2-COOH with Grignard reagents R1MgBr in the presence of nickel give stable aryl alkyl ketyl radicals 2-O--R2-, R3-C6H2-CO--R1 where R1 = CH3, C2H5, C2D5, n-C3H7 and R2,R3 = CH3, C2H5, i-C3H7, t-C4H9. The β protons of ketyl group are equivalent (splitting constant 1.25 mT) and non-equivalent (splitting constants within 0.5 to 1.5 mT) for R1 = methyl and other alkyl groups, respectively. Interaction of the γ protons with the unpaired electron was only observed in the case of R1 = n-propyl (splitting constants about 0.07 mT). The substituents R1 have but slight effect on values of splitting constants of the protons in R2,R3 and vice versa. Also splitting constants of the benzene nucleus (a4H = 0.55 mT, a6H = 0.44 mT) are only slightly affected by the substituents R1,R2,R3, which indicates dominant electron-donor effect of the oxido-anion group eliminating the relatively smaller contributions of the alkyl substituents.

The Preparation of Grignard Reagents from Magnesium Amalgams

1939 ◽  
Vol 61 (12) ◽  
pp. 3591-3591
Author(s):  
Eugene G. Rochow
Keyword(s):  
Grignard Reagents

ChemInform Abstract: THE REACTIONS OF ETHYL 2-FURANACRYLATE WITH GRIGNARD REAGENTS

1978 ◽  
Vol 9 (6) ◽  
Author(s):  
J. SALONEN ◽  
G. A. HOLMBERG
Keyword(s):  
Grignard Reagents

Reaction of α-trifluoromethylacrylic acid with various unsaturated Grignard reàgents

1993 ◽  
Vol 62 (2-3) ◽  
pp. 201-206 ◽  
Author(s):  
S. Watanabe ◽  
K. Sugahara ◽  
T. Fujita ◽  
M. Sakamoto ◽  
T. Kitazume
Keyword(s):  
Grignard Reagents
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