The Case of the Missing Ring:  Radical Cleavage of a Carbon−Carbon Bond and Implications for GFP Chromophore Biosynthesis

2007 ◽  
Vol 129 (11) ◽  
pp. 3118-3126 ◽  
Author(s):  
David P. Barondeau ◽  
Carey J. Kassmann ◽  
John A. Tainer ◽  
Elizabeth D. Getzoff
Keyword(s):  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Gfp Chromophore ◽  
Radical Cleavage ◽  
Missing Ring

Carbon Dioxide-Mediated C(sp2)–H Arylation of Primary and Secondary Benzylamines

2018 ◽  
Author(s):  
Mohit Kapoor ◽  
Pratibha Chand-Thakuri ◽  
Michael Young
Keyword(s):  
Carbon Dioxide ◽  
Transition Metal ◽  
Bond Activation ◽  
Bond Formation ◽  
Carbon Bond ◽  
Chelate Effect ◽  
Free Amine ◽  
Carbon Carbon Bond ◽  
New Strategy ◽  
Metal Catalyzed

Carbon-carbon bond formation by transition metal-catalyzed C–H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of <i>ortho</i>-arylbenzylamines, however, effective <i>ortho</i>-C–C bond formation from C–H bond activation of free primary and secondary benzylamines using Pd<sup>II</sup> remains an outstanding challenge. Presented herein is a new strategy for constructing <i>ortho</i>-arylated primary and secondary benzylamines mediated by carbon dioxide (CO<sub>2</sub>). The use of CO<sub>2</sub> is critical to allowing this transformation to proceed under milder conditions than previously reported, and that are necessary to furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, a chelate effect is demonstrated to facilitate selective monoarylation.

Palladium Deposited on Naturally Occurring Supports as a Powerful Catalyst for Carbon-Carbon Bond Formation Reactions

2015 ◽  
Vol 20 (4) ◽  
pp. 327-348 ◽  
Author(s):  
Arash Ghaderi ◽  
Mohammad Gholinejad ◽  
Habib Firouzabadi
Keyword(s):  
Bond Formation ◽  
Carbon Bond ◽  
Naturally Occurring ◽  
Carbon Carbon Bond ◽  
Bond Formation Reactions

Acetylene Radical-Cations in Carbon-Carbon Bond Forming Reactio ns

2017 ◽  
Vol 14 (3) ◽  
Author(s):  
Aleksander V. Vasilyev
Keyword(s):  
Radical Cations ◽  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Carbon Bond

Modern Organic Synthesis in the Laboratory

2008 ◽  
Author(s):  
Jie Jack Li ◽  
Chris Limberakis ◽  
Derek A. Pflum
Keyword(s):  
Organic Chemistry ◽  
Graduate Students ◽  
Organic Synthesis ◽  
Functional Group ◽  
Bond Formation ◽  
Reaction Conditions ◽  
Carbon Bond ◽  
Oxidation Reduction ◽  
Carbon Carbon Bond ◽  
Daunting Task

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

scholarly journals Deamination of Methylenecyclopropylcarbinylamine. The Formation of a Vinyl Cation by Carbon-Carbon Bond Cleavage

1970 ◽  
Vol 43 (5) ◽  
pp. 1530-1534 ◽  
Author(s):  
Akio Nishimura ◽  
Masaki Ohta ◽  
Hiroshi Kato
Keyword(s):  
Bond Cleavage ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Vinyl Cation

Scission of the carbon-carbon bond in compounds containing the triphenylmethyl group

1956 ◽  
Vol 5 (3) ◽  
pp. 299-302
Author(s):  
A. N. Nesmeyanov ◽  
V. F. Lavrushin ◽  
T. M. Shmaeva ◽  
E. G. Perevalova
Keyword(s):  
Carbon Bond ◽  
Carbon Carbon Bond

scholarly journals Front Cover: Reductive Carbon–Carbon Bond Forming Reactions with Carbonyls Mediated by Rh–H Complexes (Eur. J. Org. Chem. 42/2020)

2020 ◽  
Vol 2020 (42) ◽  
pp. 6501-6501
Author(s):  
Kazuyuki Sato ◽  
Motoyuki Isoda ◽  
Atsushi Tarui ◽  
Masaaki Omote
Keyword(s):  
Carbon Bond ◽  
Front Cover ◽  
Bond Forming ◽  
Carbon Carbon Bond ◽  
Bond Forming Reactions

Utilization of C(sp3)‐Carboxylic Acids and Their Redox‐Active Esters in Decarboxylative Carbon‒Carbon Bond Formation

2021 ◽  
Author(s):  
Sukhen Karmakar ◽  
Arundutt Silamkoti ◽  
Nicholas A Meanwell ◽  
Arvind Mathur ◽  
Arun Gupta
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Carbon Bond ◽  
Active Esters ◽  
Carbon Carbon Bond ◽  
Redox Active
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