Chemistry of Nitric Oxide with Protein-Bound Iron Sulfur Centers. Insights on Physiological Reactivity

1999 ◽  
Vol 121 (17) ◽  
pp. 4093-4100 ◽  
Author(s):  
Matthew W. Foster ◽  
J. A. Cowan
Keyword(s):  
Nitric Oxide ◽  
Physiological Reactivity ◽  
Iron Sulfur

scholarly journals Antimicrobial Activity of the Iron-Sulfur Nitroso Compound Roussin's Black Salt [Fe4S3(NO)7] on the Hyperthermophilic Archaeon Pyrococcus furiosus

2009 ◽  
Vol 75 (7) ◽  
pp. 1820-1825 ◽  
Author(s):  
Scott D. Hamilton-Brehm ◽  
Gerrit J. Schut ◽  
Michael W. W. Adams
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Agent ◽  
Pyrococcus Furiosus ◽  
Cell Lysis ◽  
Nitroso Compound ◽  
Hyperthermophilic Archaeon ◽  
New Class ◽  
Iron Sulfur ◽  
Sulfur Reductase ◽  
Potential Use

ABSTRACT The iron-sulfur nitroso compound [Fe4S3(NO)7]− is a broad-spectrum antimicrobial agent that has been used for more than 100 years to combat pathogenic anaerobes. Known as Roussin's black salt (RBS), it contains seven moles of nitric oxide, the release of which was always assumed to mediate its cytotoxicity. Using the hyperthermophilic archaeon Pyrococcus furiosus, it is demonstrated through growth studies, membrane analyses, and scanning electron microscopy that nitric oxide does not play a role in RBS toxicity; rather, the mechanism involves membrane disruption leading to cell lysis. Moreover, insoluble elemental sulfur (S0), which is reduced by P. furiosus to hydrogen sulfide, prevents cell lysis by RBS. It is proposed that S0 also directly interacts with the membranes of P. furiosus during its transfer into the cell, ultimately for reduction by a cytosolic NADPH sulfur reductase. RBS is proposed to be a new class of inorganic antimicrobial agent that also has potential use as an inert cell-lysing agent.

Iron-sulfur [2Fe-2S] nitrosyl complexes as new trend in synthesis of donors of nitric oxide for anti-aging therapy

2017 ◽  
Vol 112 ◽  
pp. 54 ◽  
Author(s):  
Sergey M. Aldoshin ◽  
Vladislav V. Bezrukov ◽  
Eugeniy N. Gorban ◽  
Vitaly K. Koltover ◽  
Nataliya A. Sanina
Keyword(s):  
Nitric Oxide ◽  
Nitrosyl Complexes ◽  
Iron Sulfur
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