Dynamics in Catalytic Asymmetric Diastereoconvergent (3 + 2) Cycloadditions with Isomerizable Nitrones and α-Keto Ester Enolates

2021 ◽  
Author(s):  
Tetsuya Ezawa ◽  
Yoshihiro Sohtome ◽  
Daisuke Hashizume ◽  
Masaya Adachi ◽  
Mai Akakabe ◽  
...  
Keyword(s):  
Keto Ester ◽  
Catalytic Asymmetric

Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 85058-85062 ◽  
Author(s):  
Mayaka Maeno ◽  
Hiroya Kondo ◽  
Etsuko Tokunaga ◽  
Norio Shibata
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Asymmetric Synthesis ◽  
Therapeutic Agent ◽  
The Self ◽  
Keto Ester ◽  
Catalytic Asymmetric Synthesis ◽  
Palladium Catalyzed ◽  
Catalytic Asymmetric ◽  
Decarboxylative Allylation

Catalytic asymmetric synthesis of fluorinated donepezil, a promising new therapeutic agent for Alzheimer's disease, was achieved.

Enantioselective preparation of C-ring fragment of cotylenin A via catalytic asymmetric intramolecular cyclopropanation of α-diazo β-keto ester

2017 ◽  
Vol 58 (10) ◽  
pp. 959-962 ◽  
Author(s):  
Kotaro Nagatani ◽  
Yunosuke Hoshino ◽  
Haruka Tezuka ◽  
Masahisa Nakada
Keyword(s):  
Keto Ester ◽  
Catalytic Asymmetric

ChemInform Abstract: Catalytic Asymmetric Hydrogenation of α-Amino-β-keto Ester Hydrochlorides Using Homogeneous Chiral Nickel-Bisphosphine Complexes Through DKR.

ChemInform ◽  
2009 ◽  
Vol 40 (17) ◽  
Author(s):  
Yasumasa Hamada ◽  
Yu Koseki ◽  
Takefumi Fujii ◽  
Tsukuru Maeda ◽  
Takuya Hibino ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Keto Ester ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Hydrogenation

Catalytic asymmetric hydrogenation of α-amino-β-keto ester hydrochlorides using homogeneous chiral nickel-bisphosphine complexes through DKR

2008 ◽  
pp. 6206 ◽  
Author(s):  
Yasumasa Hamada ◽  
Yu Koseki ◽  
Takefumi Fujii ◽  
Tsukuru Maeda ◽  
Takuya Hibino ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Keto Ester ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Hydrogenation

Rhodium-Catalyzed anti and syn Enantio- and Diastereoselective Transfer Hydrogenation of α-Amino β-Keto Ester Hydrochlorides through Dynamic Kinetic Resolution

Synthesis ◽  
2016 ◽  
Vol 48 (19) ◽  
pp. 3357-3363 ◽  
Author(s):  
Quentin Llopis ◽  
Charlène Férard ◽  
Gérard Guillamot ◽  
Phannarath Phansavath ◽  
Virginie Ratovelomanana-Vidal
Keyword(s):  
Formic Acid ◽  
Kinetic Resolution ◽  
Amino Alcohols ◽  
Hydrogen Donor ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Keto Ester ◽  
Catalytic Asymmetric ◽  
Donor Source

A mild catalytic asymmetric transfer hydrogenation of a series of α-amino β-keto ester hydrochlorides catalyzed by a rhodium(III) complex is reported. The use of the formic acid/triethylamine system as the hydrogen donor source provided the corresponding anti and syn amino alcohols with complete conversions, fair diastereoselectivities (up to 97:3 dr), and high enantioselectivities (ee up to >99%).

Catalytic Asymmetric Synthesis

1995 ◽  
Vol 191 (Part_1) ◽  
pp. 141-142
Author(s):  
G. Oehme
Keyword(s):  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric
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