Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 85058-85062 ◽  
Author(s):  
Mayaka Maeno ◽  
Hiroya Kondo ◽  
Etsuko Tokunaga ◽  
Norio Shibata
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Asymmetric Synthesis ◽  
Therapeutic Agent ◽  
The Self ◽  
Keto Ester ◽  
Catalytic Asymmetric Synthesis ◽  
Palladium Catalyzed ◽  
Catalytic Asymmetric ◽  
Decarboxylative Allylation

Catalytic asymmetric synthesis of fluorinated donepezil, a promising new therapeutic agent for Alzheimer's disease, was achieved.

Catalytic Decarboxylative Allylation of Enolcarbonates: Synthesis of Enantioenriched 3-Allyl-3’-Aryl 2-Oxindoles and Core Structure of Azonazine

2021 ◽  
Author(s):  
K. Naresh Babu ◽  
Souvik Pal ◽  
Arindam Khatua ◽  
Avishek Roy ◽  
Alakesh Bisai
Keyword(s):  
Asymmetric Synthesis ◽  
Core Structure ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric ◽  
Decarboxylative Allylation

Catalytic asymmetric synthesis of 3-allyl-3’-aryl 2-oxindoles has been shown by Pd(0)-catalyzed decarboxylative allylation of allylenol carbonates. This methodology provides access to a varitey of 2-oxindole substrates (5a-v) with an all-carbon...

Sign in / Sign up

Export Citation Format

Share Document