Anthocyanin-rich Purple Wheat Prolongs the Life Span of Caenorhabditis elegans Probably by Activating the DAF-16/FOXO Transcription Factor

2013 ◽  
Vol 61 (12) ◽  
pp. 3047-3053 ◽  
Author(s):  
Wei Chen ◽  
Dolores Müller ◽  
Elke Richling ◽  
Michael Wink
Antioxidants ◽  
2018 ◽  
Vol 7 (12) ◽  
pp. 192 ◽  
Author(s):  
Christina Saier ◽  
Inge Gommlich ◽  
Volker Hiemann ◽  
Sabrina Baier ◽  
Karoline Koch ◽  
...  

Agrimonia procera is a pharmacologically interesting plant which is proposed to protect against various diseases due to its high amount of phytochemicals, e.g., polyphenols. However, in spite of the amount of postulated health benefits, studies concerning the mechanistic effects of Agrimonia procera are limited. Using the nematode Caenorhabditis elegans, we were able to show that an ethanol extract of Agrimonia procera herba (eAE) mediates strong antioxidative effects in the nematode: Beside a strong radical-scavenging activity, eAE reduces accumulation of reactive oxygen species (ROS) accumulation and protects against paraquat-induced oxidative stress. The extract does not protect against amyloid-β-mediated toxicity, but efficiently increases the life span (up to 12.7%), as well as the resistance to thermal stress (prolongation of survival up to 22%), of this model organism. Using nematodes deficient in the forkhead box O (FoxO)-orthologue DAF-16, we were able to demonstrate that beneficial effects of eAE on stress resistance and life span were mediated via this transcription factor. We showed antioxidative, stress-reducing, and life-prolonging effects of eAE in vivo and were able to demonstrate a molecular mechanism of this extract. These results may be important for identifying further molecular targets of eAE in humans.


Genetics ◽  
2013 ◽  
Vol 194 (3) ◽  
pp. 619-629 ◽  
Author(s):  
Kathleen J. Dumas ◽  
Colin E. Delaney ◽  
Stephane Flibotte ◽  
Donald G. Moerman ◽  
Gyorgyi Csankovszki ◽  
...  

PLoS Genetics ◽  
2014 ◽  
Vol 10 (10) ◽  
pp. e1004703 ◽  
Author(s):  
Kurt Warnhoff ◽  
John T. Murphy ◽  
Sandeep Kumar ◽  
Daniel L. Schneider ◽  
Michelle Peterson ◽  
...  

2007 ◽  
Vol 81 (12) ◽  
pp. 849-858 ◽  
Author(s):  
Andreas Kampkötter ◽  
Christiane Gombitang Nkwonkam ◽  
Ruben Felix Zurawski ◽  
Claudia Timpel ◽  
Yvonni Chovolou ◽  
...  

2006 ◽  
Vol 190 (2) ◽  
pp. 191-202 ◽  
Author(s):  
Ralf Baumeister ◽  
Elke Schaffitzel ◽  
Maren Hertweck

Modulation of insulin/IGF signaling in the nematode Caenorhabditis elegans is the central determinant of the endocrine control of stress response, diapause, and aging. Mutations in many genes that interfere with, or are controlled by, insulin signaling have been identified in the last decade by genetic analyses in the worm. Most of these genes have orthologs in vertebrate genomes, and their functional characterization has provided multiple hints about conserved mechanisms for the genetic influence on aging. The emerging picture is that insulin-like molecules, through the activity of the DAF-2/insulin/ IGF-I-like receptor, and the DAF-16/FKHRL1/FOXO transcription factor, control the ability of the organism to deal with oxidative stress, and interfere with metabolic programs that help to determine lifespan.


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