The Synthesis of Some Aryl Nitrogen Mustard Derivatives of Estrogens

1967 ◽  
Vol 10 (2) ◽  
pp. 255-257 ◽  
Author(s):  
C. R. Walk ◽  
T. C. Chou ◽  
Hsi Hu. Lin
Keyword(s):  
Nitrogen Mustard ◽  
Derivatives Of

Protection of L-cells by thiols against the toxicity of sulfur mustard

1969 ◽  
Vol 47 (2) ◽  
pp. 143-151 ◽  
Author(s):  
I. G. Walker ◽  
J. F. Smith
Keyword(s):  
Nitrogen Mustard ◽  
Sulfur Mustard ◽  
Lethal Effect ◽  
Protective Mechanism ◽  
Protective Activity ◽  
L Cells ◽  
Alkyl Derivatives ◽  
Cellular Dna ◽  
Derivatives Of

The lethal effect of sulfur mustard on L-cells was reduced by pretreating the cells with dithiothreitol (DTT), aminoethylisothiuronium bromide, mercaptoethylamine, and some alkyl derivatives of this compound. The disulfides of these agents were without protective activity. The protective mechanism by which DTT operated involved a simple inactivation of the sulfur mustard. This deduction was based on the finding that alkylation by mustard of cellular DNA, RNA, and protein was reduced by DTT treatment in parallel with the reduction in toxicity of the mustard. DTT at a tolerated dose of 100 mg/kg provided scant protection to mice against the nitrogen mustard HN2.

Synthesis and Preliminary Cytotoxicity of Nitrogen Mustard Derivatives of Distamycin A.

ChemInform ◽  
2003 ◽  
Vol 34 (21) ◽  
Author(s):  
Yuqiang Wang ◽  
Susan C. Wright ◽  
James W. Larrick
Keyword(s):  
Nitrogen Mustard ◽  
Distamycin A ◽  
Derivatives Of

Synthesis and Antitumor Activity Of Novel Nitrogen Mustard Derivatives Of 2, 4, 6-Trioxo-1,3,5,2-Triazaphosphorine

2000 ◽  
Vol 165 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Shui-Ming Lu ◽  
Li-Juan Mao ◽  
Ye-Rong Xiong
Keyword(s):  
Antitumor Activity ◽  
Nitrogen Mustard ◽  
Derivatives Of

Novel phenyl nitrogen mustard and half-mustard derivatives of amidino-modified distamycin

1997 ◽  
Vol 7 (23) ◽  
pp. 2979-2984 ◽  
Author(s):  
Paolo Cozzi ◽  
Italo Beria ◽  
Giovanni Biasoli ◽  
Marina Caldarelli ◽  
Laura Capolongo ◽  
...  
Keyword(s):  
Nitrogen Mustard ◽  
Derivatives Of

scholarly journals Cytogenetic analysis of the action of carcinogens and tumour inhibitors in Drosophila melanogaster VI. The Mutagenic cell Stage Response of the Male Germ Line to the ‘Nitrogen-Mustard’ Derivatives of Amino-acids, Carboxylic acids and amines

1960 ◽  
Vol 1 (2) ◽  
pp. 173-188 ◽  
Author(s):  
O. G. Fahmy ◽  
Myrtle J. Fahmy
Keyword(s):  
Amino Acids ◽  
Nitrogen Mustard ◽  
Germ Line ◽  
Amino Group ◽  
Maximal Effect ◽  
Male Germ Line ◽  
Cell Stage ◽  
Early Spermatid ◽  
Differential Cell ◽  
Derivatives Of

The analysis of the variation in the mutation rate in the fractionated progeny of treated males, revealed a marked differential cell stage response to the various chemical series investigated. The mustard derivatives of amino-acids (particularly L-phenylalanine) exert their minimal mutagenicity on mature sperm, but possess an appreciable activity on other stages of spermatogenesis, including spermatogonia. The carboxylic-acid mustards produce their maximal effect on an early spermatid, but are practically ineffective on spermatocytes and spermatogonia. The amine mustard corresponding to the phenylalanine derivative is effective on the stages of spermiogenesis (including the early spermatids) as well as on the spermatocytes, but is inactive on the spermatogonia (at least the primary stages). The response of the gonia, therefore, is a function of the amino-acid moeity of the mutagen, and is not merely due to the presence of an amino-group in the molecule.

ChemInform Abstract: SYNTHESIS AND BIOLOGICAL ACTIVITY OF GLYCOSIDE DERIVATIVES OF NITROGEN MUSTARD

1980 ◽  
Vol 11 (34) ◽  
Author(s):  
A. MORUZZI ◽  
J.-L. MONTERO ◽  
J.-L. IMBACH
Keyword(s):  
Biological Activity ◽  
Nitrogen Mustard ◽  
Derivatives Of

Benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine: synthesis and antitumour activity

2002 ◽  
Vol 10 (5) ◽  
pp. 1611-1618 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Romeo Romagnoli ◽  
Maria Giovanna Pavani ◽  
Maria del Carmen Nunez ◽  
John P. Bingham ◽  
...  
Keyword(s):  
Nitrogen Mustard ◽  
Antitumour Activity ◽  
Derivatives Of
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